A team of biochemists at the Manchester Institute of Biotechnology has developed an isothermal biocatalytic process that can be used to manufacture therapeutic oligonucleotides in large volumes. In their paper published in ...
Cancer is the second leading cause of death in Switzerland. Among the different types of cancers, non-small cell lung cancer (NSCLC) kills the most patients and remains largely incurable. Unfortunately, even newly approved ...
Cell & Microbiology
Oct 6, 2022
0
68
A group of Skoltech researchers under Dr. Olga Sergeeva's supervision studied the functions of a long non-coding RNA, which is "read" from the genome, but does not carry the information about protein structure. In experiments ...
Cell & Microbiology
Jul 7, 2022
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5
Many intractable diseases are the result of a genetic mutation. Genome editing technology promises to correct the mutation and thus new treatments for patients. However, getting the technology to the cells that need the correction ...
Bio & Medicine
Dec 9, 2021
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152
Gene silencing therapies are used to interfere with, or 'silence', the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies ...
Molecular & Computational biology
Jul 6, 2021
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4
Chemically synthesized short DNA sequences are extremely important ingredients with countless uses in research laboratories, hospitals, and in industry, like in the method for identifying COVID-19. Phosphoramidites are necessary ...
Materials Science
May 12, 2021
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16
RUDN biochemists found a way to reduce the activity of telomerase (the enzyme of cell immortality) 10-fold. The discovery could lead to new antitumor drugs and give a better understanding of how the activity of the enzyme ...
Biochemistry
Feb 12, 2019
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11
A team of researchers at the University of California has found a way to synthesize multiple genes from a group of microarray-generated oligonucleotides. In their paper published in the journal Science, the group describes ...
Short single strands of DNA can self-assemble to create DNA nanostructures. Scientists based in Munich, Germany, have prepared not only assembled, but even catenated oligonucleotide structures to form chain-armor DNA nanotubes ...
Materials Science
Jun 3, 2015
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23
Therapeutic oligonucleotide analogs represent a new and promising family of drugs that act on nucleic acid targets such as RNA or DNA; however, their effectiveness has been limited due to difficulty crossing the cell membrane. ...
Bio & Medicine
Jan 27, 2015
0
27
