The nuclear receptor–binding SET Domain (NSD) family protein is closely connected with many cancers. However, their molecular mechanism remains unknown.
Biotechnology
Dec 24, 2020
0
193
One feature of cell division has long puzzled scientists. The nucleus briefly disappears, leaving the cell's DNA exposed. Normally, bare DNA indicates a viral infection and triggers enzymatic alarms that alert the immune ...
Cell & Microbiology
Sep 15, 2020
0
78
New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells—including cancer cells—regulate their genes.
Molecular & Computational biology
Jun 4, 2020
0
113
The DNA of a single cell is two to three meters long end-to-end. To fit in the nucleus and function correctly, DNA is packaged around specialized proteins. These DNA-protein complexes are called nucleosomes, and they are ...
Biotechnology
Nov 21, 2019
0
126
The inheritance, not only of DNA, but of changes to proteins that package it, maintains the identity of cells as they multiply, a new study finds.
Cell & Microbiology
Oct 31, 2019
0
95
UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...
Molecular & Computational biology
May 30, 2019
0
82
Two scientists at the Johns Hopkins University School of Medicine have unraveled aspects of how DNA organizes and preserves genetic information. Newly published research by Cynthia Wolberger, Ph.D., and James Berger, Ph.D., ...
Molecular & Computational biology
May 22, 2019
0
6
The way DNA folds largely determines which genes are read out. John van Noort and his group have quantified how easily rolled-up DNA parts stack. This costs less energy than previously assumed. Publication in Biophysical ...
Biochemistry
Nov 12, 2018
0
23
LMU researchers have, for the first time, systematically determined the positioning of the packing units of the fruit fly genome and discovered a new protein that defines their relationship to the DNA sequence.
Plants & Animals
Nov 5, 2018
0
11
A team of researchers at the University of Utah has found that nucleosomes can inhibit CRISPR/Cas9 cleavage efficiency. In their paper published in Proceedings of the National Academy of Sciences, the group describes testing ...
