RIKEN researchers have shown how a gene-reading enzyme manages to dismantle bead-like structures of DNA and reassemble them at high speed, without disrupting the integrity of genomic organization. Their findings, now published ...
Cell & Microbiology
Nov 17, 2022
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38
A key protein for converting adult stem cells into cells that resemble embryonic stem cells has been visualized in unprecedented detail by an international team of researchers around Hans Schöler and Vlad Cojocaru of the ...
Cell & Microbiology
Sep 22, 2022
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16
Human life hinges on the ability of our cells to cram six feet of DNA into a 10-micron nucleus—equivalent to fitting a mile of string inside one green pea. But stuffing genes into cramped quarters is only half the battle. ...
Molecular & Computational biology
Sep 30, 2021
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811
How can proteins bind DNA in the cell nucleus, where it is present in form of chromatin, tightly wrapped around histones and therefore mostly inaccessible? Recently, several studies began to uncover the various strategies ...
Cell & Microbiology
Jun 29, 2021
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9
A team of researchers working at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France, has found that the MeCP2 protein binds to DNA in a way that prevents it from being wrapped up in nucleosomes. ...
Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for Molecular Biomedicine in Münster (Germany) used computer simulations to reveal in atomic detail how a short piece of DNA ...
Biotechnology
Jun 3, 2021
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14
Scientists at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) in Japan have developed a technology that produces high-resolution simulations of one of the basic units of our genomes, called the ...
Molecular & Computational biology
Jun 1, 2021
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3
Northwestern Medicine scientists have developed a new method to analyze the protein composition of intact nucleosomes without losing combinatorial information present in chromatin. The technique, called Nuc-MS, could help ...
Biotechnology
May 24, 2021
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12
Gene editing with CRISPR enzymes inside living cells could become more effective and accurate after researchers at The University of Texas at Austin unveiled how inner workings can help or hinder the process.
Biotechnology
Mar 10, 2021
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107
Chromatin remodelers are needed to take nucleosomes away from DNA in order to make room for transcription factors to bind, and regulate the activity of our genes. It has been unclear how dynamic this process is. Researchers ...
Evolution
Feb 9, 2021
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7
