News tagged with nucleosome

Scientists find DNA is packaged like a yoyo

To pack two meters of DNA into a microscopic cell, the string of genetic information must be wound extremely carefully into chromosomes. Surprisingly the DNA's sequence causes it to be coiled and uncoiled much like a yoyo, ...

dateMar 16, 2015 in Cell & Microbiology
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Unspooling DNA from nucleosomal disks

The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal ...

dateMay 23, 2013 in Biochemistry
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How proteins read meta DNA code

Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read ...

dateMar 19, 2013 in Biotechnology
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Regulating hematopoietic differentiation

Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms underlying this ...

dateOct 05, 2012 in Cell & Microbiology
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