News tagged with nucleosome

Unspooling DNA from nucleosomal disks

The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal ...

dateMay 23, 2013 in Biochemistry
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How proteins read meta DNA code

Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read ...

dateMar 19, 2013 in Biotechnology
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Regulating hematopoietic differentiation

Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms ...

dateOct 05, 2012 in Cell & Microbiology
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A foot in the door to genetic information

In the cell nucleus, DNA wraps around what are called histone proteins, forming regularly spaced spherical bodies called nucleosomes. Thus, large portions of the genetic material are inaccessible to the gene reading machinery. ...

dateMar 07, 2012 in Biochemistry
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Elusive Z- DNA found on nucleosomes

New research published in BioMed Central's open access journal Cell & Bioscience is the first to show that left-handed Z-DNA, normally only found at sites where DNA is being copied, can also form on nucleosomes.

dateJan 20, 2012 in Cell & Microbiology
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