Scientists observe human neurodegenerative disorder in fruit flies

A team of scientists from The Scripps Research Institute, Katholeike Universiteit Leuven, and the University of Antwerp, Belgium, among other institutions, has created a genetically modified fruit fly that mimics key features ...

Cells get two chances, not just one, to fix their mistakes

Cells have two chances to fix the same mistake in their protein-making process instead of just one - a so-called proofreading step - that had previously been identified, according to new research.

First mouse model with mitochondrial tRNALeu mutation developed

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial ...

Cellular mechanism that allows stem cells to maintain their state

Embryonic stem cells can give rise to every cell type in the body. A team of researchers from Sweden, in collaboration with groups in Switzerland and Canada, has now identified a cellular mechanism that is important for the ...

Protein complex may help prevent neurodegenerative diseases

Researchers from the Universities of Konstanz (Germany), Leeds (U.K.) and Stanford (U.S.) have discovered that the nascent polypeptide-associated complex (NAC) prevents the aggregation of proteins associated with several ...

How nerve cells control misfolded proteins

Researchers have identified a protein complex that marks misfolded proteins, stops them from interacting with other proteins in the cell, and directs them toward disposal. In collaboration with the neurology department at ...

Programming synthetic molecular codes to turn genes 'on'

A team of researchers in Japan developed a synthetic molecular code to script gene activation. The process, described in the Journal of the American Chemical Society, could lead to future gene-based therapies for a wide array ...

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