News tagged with neuroblastoma
New method will triple amount of genetic information from newborn blood spot screenings
Van Andel Research Institute (VARI) researchers have developed a method that can yield more information from archived newborn blood that has implications for a vast array of research, including population health studies and ...
Jan 12, 2011 |
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New gene for childhood cancer neuroblastoma discovered
Pediatric cancer researchers have identified variations in a gene as important contributors to neuroblastoma, the most common solid cancer of early childhood. The study team, led by researchers at The Children's Hospital ...
Dec 01, 2010 |
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Black children more likely to die from neuroblastoma, study finds
Black, Asian, and Native American children are more likely than white and Hispanic children to die after being treated for neuroblastoma, according to new research on the pediatric cancer. The study, of more than 3,500 patients ...
Nov 22, 2010 |
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Scientists find new twist on drug screening to treat common childhood cancer
A study led by scientists at The Hospital for Sick Children (SickKids) reveals a new method of identifying drugs to treat children suffering from fatal cancers for which an effective treatment has not been found. Rather than ...
Aug 18, 2010 |
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Aggressive Approach to Childhood Cancer Worth Risks, Review Finds
Neuroblastoma is among the most common of childhood cancers and fortunately, some children will get better spontaneously. Yet for children with high-risk disease the outlook is poor: more than half will relapse despite chemotherapy.
May 14, 2010 |
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Researchers fishing for cancer cure discover active DHA derivatives
The next treatment for cancer might come from fish says a new research report published in the March 2010 print edition of the FASEB Journal. In the report, scientists show that the omega-3 fatty acid, "docosahexaenoic acid" ...
Mar 01, 2010 |
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New DNA technique leads to a breakthrough in child cancer research
Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden and Karolinska Institutet have used novel technology to reveal the different genetic patterns of neuroblastoma, an aggressive form of childhood ...
Feb 22, 2010 |
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Research shows power of FRET-based approach for distinguishing among distinct states of proteins
In the December 2009 issue of the Journal of General Physiology, Moss et al. report a comprehensive investigation employing Förster resonance energy transfer (FRET) to study the {gamma}-amino acid (GABA) transporter GAT1, ...
Medicine & Health / Medical research
Nov 30, 2009 |
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Antitumor activity of nutlin-3 in neuroblastoma with wild-type p53
The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity, according to a new study published online November 10 in the Journal of the National Cancer In ...
Nov 10, 2009 |
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Long-term health and social outcomes for neuroblastoma survivors
Survivors of the childhood cancer neuroblastoma are eight times more likely to have chronic health conditions, less likely to be married, and more likely to have lower incomes than their siblings, according to a study published ...
Jul 31, 2009 |
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Protein that promotes cancer cell growth identified
Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer ...
Jul 24, 2009 |
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Gene findings revealing reasons for neuroblastoma risk
Two new studies from The Children's Hospital of Philadelphia advance the search for genetic events that result in neuroblastoma, a puzzling, often-deadly type of childhood cancer.
Jun 17, 2009 |
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Researchers identify gene that regulates tumors in neuroblastoma
Virginia Commonwealth University researchers have identified a gene that may play a key role in regulating tumor progression in neuroblastoma, a form of cancer usually found in young children. Scientists hope the finding ...
Jun 01, 2009 |
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Immunotherapy effective against neuroblastoma in children
A phase III study has shown that adding an antibody-based therapy that harnesses the body's immune system resulted in a 20 percent increase in the number of children living disease-free for at least two years with neuroblastoma. ...
May 14, 2009 |
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Novel cancer drug reduces neuroblastoma growth by 75 percent
Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found a new drug that restricts the growth of neuroblastoma, a childhood brain cancer. The pre-clinical study was ...
Apr 23, 2009 |
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Neuroblastoma
Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy, with an annual incidence of about 650 new cases per year in the US. Close to 50 percent of neuroblastoma cases occur in children younger than two years old. It is a neuroendocrine tumor, arising from any neural crest element of the sympathetic nervous system or SNS. It most frequently originates in one of the adrenal glands, but can also develop in nerve tissues in the neck, chest, abdomen, or pelvis.
Neuroblastoma is one of the few human malignancies known to demonstrate spontaneous regression from an undifferentiated state to a completely benign cellular appearance.
A disease exhibiting extreme heterogeneity, neuroblastoma is stratified into three risk categories: low, intermediate, and high risk. Low-risk disease is most common in infants and highly curable with observation only or surgery, whereas high-risk disease is difficult to cure even with the most intensive multi-modal therapies available.
Note: Esthesioneuroblastoma, also known as olfactory neuroblastoma, is believed to arise from the olfactory epithelium and its classification remains controversial. However, since it is not a sympathetic nervous system malignancy it is a distinct clinical entity and is not to be confused with neuroblastoma.
For more information about Neuroblastoma, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
