News tagged with mutant protein
Ultraviolet protection molecule in plants yields its secrets
Lying around in the sun all day is hazardous not just for humans but also for plants, which have no means of escape. Ultraviolet (UV) radiation from the sun can damage proteins and DNA inside cells, leading ...
Feb 09, 2012 |
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Neutrons provide first sub-nanoscale snapshots of Huntington's disease protein
Researchers at the Department of Energy's Oak Ridge National Laboratory and the University of Tennessee have for the first time successfully characterized the earliest structural formation of the disease type ...
May 18, 2011 |
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Mutant prions help cells foil harmful protein misfolding
Romping clumps of misfolded proteins are prime suspects in many neurological disorders including Alzheimer's, Parkinson's, and Creutzfeld-Jakob Disease. Those diseases are devastating and incurable, but a team of biologists ...
Mar 20, 2011 |
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Study traces possible role of damaged DNA in tumor development
DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.
Mar 04, 2011 |
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Most common brain cancer may originate in neural stem cells
University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points ...
Jun 01, 2009 |
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HIV pays a price for invisibility
Mutations that help HIV hide from the immune system undermine the virus's ability to replicate, show an international team of researchers in the April 13 issue of the Journal of Experimental Medicine. The study was publis ...
Medicine & Health / HIV & AIDS
Apr 13, 2009 |
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When it comes to sleep research, fruit flies and people make unlikely bedfellows
You may never hear fruit flies snore, but rest assured that when you're asleep they are too. According to research published in the January 2009 issue of the journal Genetics, scientists from the University of Missouri-Kansas City h ...
Biology /
Jan 13, 2009 |
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Huntington's disease protein has broader effects on brain, study shows
In Huntington's disease, the mutant protein known as huntingtin leads to the degeneration of a part of the brain known as the basal ganglia, causing the motor disturbances that represent one of the most defining features ...
Medicine & Health / Medical research
Apr 05, 2011 |
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Secretions of the mind
A molecule called calcium-dependent activator protein for secretion 2 (CAPS2) promotes the secretion of a neurotrophic factor that is critical for the proper development and survival of networks of interneurons ...
Medicine & Health / Medical research
Feb 25, 2011 |
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'Smart drug' targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
A new oral drug caused dramatic shrinkage of a patient's rare, aggressive form of soft-tissue cancer that was driven by an abnormally activated protein, physician-scientists from Dana-Farber Cancer Institute report in the ...
Oct 27, 2010 |
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Neuron-damaging mechanism discovered in mouse model of inherited amyotrophic lateral sclerosis
New research uncovers what may be a primary neuron-damaging insult that occurs in an inherited form of a devastating neurodegenerative disorder. The study, published by Cell Press in the August 26th issue of the journal Neuron, descri ...
Medicine & Health / Medical research
Aug 25, 2010 |
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SUMO works with replication protein A complex to repair DNA
A team of investigators led by a physician-scientist at The University of Texas MD Anderson Cancer Center has shown for the first time that the small protein SUMO can team up with the replication protein A (RPA) complex to ...
Aug 12, 2010 |
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Huntington's disease discovery provides new hope for treatment
Australian scientists have identified the behaviour of the mutant protein 'huntingtin' which leads to the fatal Huntington's disease providing potential targets to treat the disease, a University of Melbourne study reveals.
Jul 28, 2010 |
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Defective protein is a double hit for ataxia
The neurodegenerative disease spinocerebellar ataxia type 5 (SCA5) damages nerve cells in two ways. University of Minnesota researchers now report that the defective protein responsible for the disease cuts ...
Medicine & Health / Medical research
Apr 05, 2010 |
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Researchers find new method of fixing broken proteins to treat genetic diseases
Researchers at Fox Chase Cancer Center have demonstrated how it could be possible to treat genetic diseases by enhancing the natural ability of cells to restore their own mutant proteins. In particular, they found that drugs ...
Jan 15, 2010 |
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