A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology.
May 06, 2013
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The notion that each gene can only codify for a single protein has been challenged for some years. Yet, the functional outcomes that may result from genes encoding more than one protein are still largely unknown.
Mar 22, 2013
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(Phys.org)—While studying a mutant strain of yeast, Purdue University researchers may have found a new target for drugs to combat cholesterol and fungal diseases.
Feb 25, 2013
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Rice (Oryza sativa) is an important dietary source of cadmium and can accumulate very high levels of manganese without toxic effects. However so far there has been little understanding of the uptake and transport ...
Sep 21, 2012
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The first step in gene expression is the exact copying of a segment of DNA by the enzyme known as RNA polymerase II, or pol II, into a mirror image RNA. Scientists recognize that pol II does not transcribe ...
Aug 22, 2012
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Transcription is a cellular process by which genetic information from DNA is copied to messenger RNA for protein production. But anticancer drugs and environmental chemicals can sometimes interrupt this flow of genetic information ...
Aug 21, 2012
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In an advance that could be used in masks to protect against nerve gas, scientists are reporting development of proteins that are up to 15,000 times more effective than their natural counterpart in destroying ...
Aug 08, 2012
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Lying around in the sun all day is hazardous not just for humans but also for plants, which have no means of escape. Ultraviolet (UV) radiation from the sun can damage proteins and DNA inside cells, leading ...
Feb 09, 2012
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Researchers at the Department of Energy's Oak Ridge National Laboratory and the University of Tennessee have for the first time successfully characterized the earliest structural formation of the disease type ...
May 18, 2011
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In Huntington's disease, the mutant protein known as huntingtin leads to the degeneration of a part of the brain known as the basal ganglia, causing the motor disturbances that represent one of the most defining features ...
Apr 05, 2011
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Romping clumps of misfolded proteins are prime suspects in many neurological disorders including Alzheimer's, Parkinson's, and Creutzfeld-Jakob Disease. Those diseases are devastating and incurable, but a team of biologists ...
Mar 20, 2011
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DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.
Mar 04, 2011
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A molecule called calcium-dependent activator protein for secretion 2 (CAPS2) promotes the secretion of a neurotrophic factor that is critical for the proper development and survival of networks of interneurons ...
Feb 25, 2011
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The University of Massachusetts Medical School (UMMS) and Lundbeck Inc. today announced a research collaboration aimed at further development of a targeted therapy to slow or halt the progression of Huntington's disease (HD).
Jan 28, 2011
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A new oral drug caused dramatic shrinkage of a patient's rare, aggressive form of soft-tissue cancer that was driven by an abnormally activated protein, physician-scientists from Dana-Farber Cancer Institute report in the ...
Oct 27, 2010
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