News tagged with mutant p53 protein
Most common brain cancer may originate in neural stem cells
University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points ...
Jun 01, 2009 |
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Search results for mutant p53 protein
Cancer is a p53 protein aggregation disease
Protein aggregation, generally associated with Alzheimer's and mad cow disease, turns out to play a significant role in cancer. In a paper published in Nature Chemical Biology, Frederic Rousseau and Joost Schymkowitz of VIB ...
Mar 29, 2011 |
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Researchers find new role for cancer protein p53
The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are ...
Mar 02, 2011 |
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Study on skin formation suggests strategies to fight skin cancer
In a study published in the journal Developmental Cell, Sarah Millar PhD, professor of Dermatology and Cell & Developmental Biology at the University of Pennsylvania School of Medicine, and colleagues demons ...
Dec 06, 2010 |
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Restoring the gene for cancer protein p53 slows spread of advanced tumors
(PhysOrg.com) -- In a new study to be published in the Nov. 25 issue of Nature, MIT cancer biologists show that restoring the protein p53's function in mice with lung cancer has no effect early in tumor develo ...
Nov 24, 2010 |
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A better way to target tumors
In the past 40 years, scientists have learned a great deal about how cells become cancerous. Some of that knowledge has translated to new treatments, but most of the time doctors are forced to rely on standard ch ...
Nov 15, 2010 |
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Scientists show TAp63 suppresses cancer metastasis
Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs, researchers at The University of Texas MD Anderson Cancer Center ...
Oct 20, 2010 |
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Use the common cold virus to target and disrupt cancer cells?
A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted ...
Aug 25, 2010 |
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'Cheater' Cells May Spur Cancer Growth
(PhysOrg.com) -- A new study from the Yale School of Medicine reveals a biological struggle within tissue that allows some damaged cells to survive and proliferate, eventually leading to cancer. The study ...
Apr 01, 2010 |
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Loss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise, Study Finds
(PhysOrg.com) -- A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrup ...
Oct 15, 2009 |
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DNA-damaged cells communicate with neighbors to let them know they're in trouble
When cells experiencing DNA damage fail to repair themselves, they send a signal to their neighbors letting them know they're in trouble. The discovery, which shows that a process dubbed the DDR (DNA Damage Response) also ...
Jul 13, 2009 |
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List of search results for mutant p53 protein
