Developing a machine learning model to explore DNA methylation

A Northwestern Medicine study has detailed the development of a machine learning model to predict DNA methylation status in cell-free DNA by its fragmentation patterns, according to findings published in Nature Communications.

Biologists reveal how gyrase resolves DNA entanglements

Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in every cell in the body ...

Novel role for metabolites in cellular metabolism discovered

Investigators led by Issam Ben-Sahra, Ph.D., associate professor of Biochemistry and Molecular Genetics, have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used ...

Researchers focus on finding flaws in superbugs' armor

Recent years have seen the rise of bacterial pathogens that have developed resistance to antibiotics. One such superbug, carbapenem-resistant Acinetobacter baumannii (CRAB), kills hundreds of critically ill patients in the ...

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Molecular genetics

Molecular genetics is the field of biology that studies the structure and function of genes at a molecular level. The field studies how the genes are transferred from generation to generation. Molecular genetics employs the methods of genetics and molecular biology. It is so-called to differentiate it from other sub fields of genetics such as ecological genetics and population genetics. An important area within molecular genetics is the use of molecular information to determine the patterns of descent, and therefore the correct scientific classification of organisms: this is called molecular systematics.

Along with determining the pattern of descendants, molecular genetics helps in understanding genetic mutations that can cause certain types of diseases. Through utilizing the methods of genetics and molecular biology, molecular genetics discovers the reasons why traits are carried on and how and why some may mutate.

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