BridgIT, a new tool for orphan and novel enzyme reactions

Effective protein engineering can give us control over the generated products inside a cell. However, for many of the biochemical reactions responsible for these products, we don't we don't know the specific protein or enzyme-producing ...

Understanding metabolic processes through machine learning

Bioinformatics researchers at Heinrich Heine University Düsseldorf (HHU) and the University of California at San Diego (UCSD) are using machine learning techniques to better understand enzyme kinetics and thus also complex ...

New targets in the battle against antibiotic resistance

Bacteria are increasingly resistant to available antibiotics. A team of chemists from the Technical University of Munich (TUM) have now identified important enzymes in the metabolism of staphylococci. Blocking these enzymes ...

CasPER—a new method for diversification of enzymes

A new study published in the Metabolic Engineering Journal describes a method based on CRISPR/Cas9, which enables flexible engineering of essential and nonessential enzymes without additional engineering. This has multiple ...

Flavins keep a handy helper in their pocket

In human cells, vitamins often serve as the precursors of cofactors—non-proteins that are an essential part of enzymes. Among them are the flavins, derived from vitamin B2.

A novel effect of epigenetic drugs on metabolic activity

Using the fruit fly Drosophila melanogaster as a model system in a novel technique, Ludwig Maximilian University of Munich researchers have uncovered a novel effect of epigenetic drugs on metabolic activity

Changing enzymes for clean energy and disease prevention

β-glycosidases are enzymes that play many roles in nature. They can play a role in metabolic disorders and can break down tough plant fibers. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean ...

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