Turn out the light: 'Switch' determines cancer cell fate
(Phys.org) —Like picking a career or a movie, cells have to make decisions – and cancer results from cells making wrong decisions.
(Phys.org) —Like picking a career or a movie, cells have to make decisions – and cancer results from cells making wrong decisions.
RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics. In a study presented in the April 25 issue of the journal Cell, researchers from T ...
(Phys.org) —Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different ...
Modern medicine is largely based on treating patients with "small-molecule" drugs, which include pain relievers like aspirin and antibiotics such as penicillin.
(Phys.org)—Machines don't always run smoothly – phone calls drop, computers crash and cars stall.
Whitehead Institute researchers have determined that DNA transcription, the process that produces messenger RNA (mRNA) templates used in protein production, also runs in the opposite direction along the DNA to create corresponding ...
Histone proteins are the proteins that package DNA into chromosomes. Every time the cell replicates its DNA it must make large amounts of newly made histones to organize DNA within the nucleus.
(Phys.org)—A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein ...
Sperm give new embryos more than just a copy of their genes: they also contribute RNAs, molecules similar to DNA that play many essential roles in switching genes on or off, and in regulating how much protein ...
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new approach to alter the function of RNA in living cells by designing molecules that recognize and disable RNA targets. As a proof ...
For a tiny embryo to grow into an entire fruit fly, mouse or human, the correct genes in each cell must turn on and off in precisely the right sequence. This intricate molecular dance produces the many parts of the whole ...
It is well known that many mammals are able to adjust the ratio of male and female young depending on the surrounding conditions at the time of conception. A recent study in the group of Christine Aurich ...
At crucial points in the metabolism of all organisms, a protein with the unwieldy name of Translation Elongation Factor P (EF-P, for short) takes center stage. What it actually does during protein synthesis has only now been ...
(Phys.org)—The nucleic acid RNA is an essential part of the critical process by which the cells in our bodies manufacture proteins. But noncoding RNAs also exist whose sequences, while not converted into ...