A powerful technique for tracking a protein's fleeting shape changes
Researchers at Weill Cornell Medicine have developed a powerful, new technique to generate "movies" of changing protein structures and speeds of up to 50 frames per second.
Researchers at Weill Cornell Medicine have developed a powerful, new technique to generate "movies" of changing protein structures and speeds of up to 50 frames per second.
Molecular & Computational biology
Apr 17, 2024
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Researchers from The Australian National University (ANU) have made a discovery about a little understood protein in the human body that could help treat diseases that cause seizures, including epilepsy. The study is published ...
Cell & Microbiology
Apr 4, 2024
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A new study provides insights into how a family of immune proteins in plants confers disease resistance. The study builds on previous research by the same research group, which highlighted the structural similarities of this ...
Molecular & Computational biology
Mar 28, 2024
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Chimeric antigen receptors (CARs) are synthesized membrane proteins that enable lymphocytes to recognize and respond to the specific antigens of target cells. Despite the impressive efficacy of CAR-T cell therapy in treating ...
Bio & Medicine
Mar 15, 2024
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An international team of researchers has succeeded in "filming" the activation of an important receptor. They froze the involved molecules at different points in time and photographed them under the electron microscope. They ...
Molecular & Computational biology
Mar 13, 2024
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Cells form adhesion structures to anchor themselves in their environment. The coordinated assembly and disassembly of these adhesions also enables cells to move from one place to another.
Cell & Microbiology
Mar 13, 2024
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Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed ...
Biochemistry
Mar 13, 2024
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Mitochondria are organelles that are known for providing the energy currency that fuels chemical reactions within cells, but they are also involved in other important processes vital for cell health including the innate immune ...
Molecular & Computational biology
Mar 1, 2024
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Researchers at the University of Alberta have uncovered what they say has been the missing puzzle piece ever since the genetic code was first cracked.
Cell & Microbiology
Feb 28, 2024
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224
Drug development is currently an extremely long, expensive and inefficient process. Findings generated in a lab are often very hard to replicate once translated into animal models or in humans.
Biotechnology
Feb 26, 2024
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A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle. More than half of all proteins interact with membranes.
Biological membranes consist of a phospholipid bilayer and a variety of proteins that accomplish vital biological functions. Structural proteins are attached to microfilaments in the cytoskeleton which ensures stability of the cell. Cell recognition proteins allow cells to identify each other and interact. Such proteins are involved in immune response, for example. Membrane enzymes produce a variety of substances essential for cell function. Membrane receptor proteins serve as connection between the cell's internal and external environments. Finally, transport proteins play an important role in the maintenance of concentrations of ions. These transport proteins come in two forms: carrier proteins and channel proteins. Carrier proteins are involved in using the energy released from ATP being broken down to facilitate active transport and ion exchange. These processes ensure that useful substances are able to enter the cell and that toxic substances are pumped out of the cell.
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