In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Profes ...
Mar 01, 2013
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Malignant glioma is generally a death sentence for patients. These tumors, which arise from non-neuronal cells within the brain, grow quickly and aggressively, and contain a core population of glioma stem ...
Nov 07, 2012
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Medical scientists know this about glioblastoma multiforme: the malignant brain tumor is aggressive, it is elusive, and it appears in different permutations.
Apr 04, 2011
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Throwing stones at castle walls is one way to attack an enemy, but sneaking inside makes the target much more vulnerable.
Mar 29, 2011
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John Moran was 27 years old when he underwent a long-shot brain surgery for what appeared to be a malignant tumor that would almost certainly be fatal.
Mar 24, 2011
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Mutations in three pathways important for suppressing tumors cooperate to launch glioblastoma, an aggressive brain tumor that strikes children and adults. But new research from St. Jude Children's Research Hospital scientists ...
Mar 14, 2011
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St. Jude Children's Research Hospital investigators have identified key components of a signaling pathway that controls the departure of neurons from the brain niche where they form and allows these cells ...
Nov 25, 2010
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One of the human body's most powerful defensive tools, the blood-brain barrier is a chemical labyrinth that prevents toxins and viruses in the bloodstream from reaching the brain. This foolproof security system, however, ...
Jul 27, 2010
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Despite grim prognoses and aggressive treatments, cancer patients suffering from malignant gliomas -- primary brain tumors -- often rate their quality of life more optimistically than their caregivers do, according to a new ...
May 20, 2010
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Glioblastoma is a guileful enemy. While most of the brain tumor can often be removed surgically, in virtually every case the tumor reappears. One reason for this is that sporadic, infiltrative tumor cells will remain in the ...
Apr 13, 2010
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The most common form of malignant brain cancer in adults, glioblastoma multiforme (GBM), is not a single disease but appears to be four distinct molecular subtypes, according to a study by the Cancer Genome Atlas (TCGA) Research ...
Jan 19, 2010
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Duke University Medical Center researchers have figured out how stem cells in the malignant brain cancer glioma may be better able to resist radiation therapy. And using a drug to block a particular signaling pathway in these ...
Dec 02, 2009
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Neurosurgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center performed the world's first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patient's malignant brain tumor. This novel ...
Nov 17, 2009
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The first national treatment guidelines for brain metastases, which account for nearly 500,000 new cancers annually in the United States, were released today at the Congress of Neurological Surgeons in New Orleans.
Oct 26, 2009
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Initial chemotherapy alone after surgery is just as successful as initial radiation therapy for patients from whom a very malignant brain tumor (anaplastic glioma) was removed. With this treatment, the patients survive on ...
Oct 01, 2009
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