Related topics: cells · cell membrane · protein · diabetes · heart disease

Efficient mRNA delivery by branched lipids

Messenger RNA (mRNA) are biological molecules that transfer the information coded by genes in the nucleus to the cytoplasm for protein synthesis by ribosomes. mRNA sequences can be designed to encode specific proteins; the ...

Pacemaker channel discovery could lead to better heart drugs

The mechanism by which fat-related molecules called lipids regulate pacemaker ion channel proteins, which help control the heart rhythm, has been revealed in a study from researchers at Weill Cornell Medicine.

Bacterial armor plating has implications for antibiotics

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armor, which has far-reaching implications for the development of ...

How a key immune protein is regulated in the cell

Scientists at EPFL have determined how a protein that is critical in our first line of immune defense is regulated in the cell to prevent autoinflammatory diseases.

Lipid expansion microscopy uses 'power of click chemistry'

Lipids—fats—make great walls for cells and organelles because they are water resistant and dynamic. But those same characteristics also make them hard to image using expansion microscopy, a technique that works for magnifying ...

New understanding of the inner world of lysosomes

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells. The findings, ...

New cryo-EM images shed light on Wnt signaling

Using UT Southwestern's Cryo-Electron Microscopy Facility, researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and crucial for Wnt signaling activation. The findings, reported ...

'Youngest' antibiotic kills bacteria via a new two-step mechanism

Scientists at Utrecht University have discovered a new mechanism antibiotics use to kill bacteria. The antibiotic teixobactin uses a dual molecular strategy: it blocks the bacterial cell wall synthesis and destructs the cell ...

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