News tagged with ligand
Study challenges conventional theory of modern drug design
Scientists from The Scripps Research Institute have uncovered new evidence that challenges the current theory about a process key to the way modern drugs are designed and how they work in the human body.
Oct 10, 2010 |
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Chemists design 'tunable,' cloaked, toxin delivery system to kill tumors from within
(PhysOrg.com) -- Researchers led by University of Massachusetts Amherst chemist Vincent Rotello have demonstrated that they can deliver a dormant toxin into a specific site such as a tumor for anti-cancer ...
Oct 04, 2010 |
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Researchers discover genetic risk factor for testicular cancer
Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer. Testicular cancer is the most common cancer among ...
May 31, 2009 |
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We need to talk: How cells communicate to activate notch
During formation of multi-cellular organisms, cells need to talk to each other to make critical decisions as to what kind of cell to become, as well as when and where to become that cell type. The Notch signaling system allows ...
May 31, 2012 |
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Discovery of new catalyst promises cheaper, greener drugs
A chemistry team at the University of Toronto has discovered environmentally-friendly iron-based nanoparticle catalysts that work as well as the expensive, toxic, metal-based catalysts that are currently in wide use by the ...
Nanotechnology / Nanomaterials
Mar 27, 2012 |
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Scientists paint new picture of dance between protein and binding partners
Using a blend of technologies, scientists from the Florida campus of The Scripps Research Institute have painted a new picture of how biochemical information can be transmitted through the modification of a protein. Previously, ...
Jan 10, 2012 |
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Nanotechnology researchers develop new strategy to deliver chemotherapy to prostate cancer cells
Honing chemotherapy delivery to cancer cells is a challenge for many researchers. Getting the cancer cells to take the chemotherapy "bait" is a greater challenge. But perhaps such a challenge has not been met with greater ...
Nanotechnology / Bio & Medicine
Jan 09, 2012 |
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Nanocrystals go bare: Stripping material’s tiny tethers
(PhysOrg.com) -- Researchers with the DOE's Lawrence Berkeley National Laboratory have discovered a universal technique for stripping nanocrystals of tether-like molecules that until now have posed as obstacles ...
Nanotechnology / Nanomaterials
Dec 09, 2011 |
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In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
By nestling quantum dots in an insulating egg-crate structure, researchers at the Harvard School of Engineering and Applied Sciences (SEAS) have demonstrated a robust new architecture for quantum-dot light-emitting devices ...
Nov 15, 2011 |
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Chemists reveal the force within you
A new method for visualizing mechanical forces on the surface of a cell, reported in Nature Methods, provides the first detailed view of those forces, as they occur in real-time.
Nov 09, 2011 |
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Nuclear receptors battle it out during metamorphosis in new fruit fly model
Growing up just got more complicated. Thomas Jefferson University biochemistry researchers have shown for the first time that the receptor for a major insect molting hormone doesn't activate and repress genes ...
Oct 06, 2011 |
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Positioning and pinching slow proton movement in catalyst
Twisting and pinching slow a catalyst's ability to generate energy from hydrogen, according to scientists at Pacific Northwest National Laboratory's Center for Molecular Electrocatalysis. In converting hydrogen to electricity, ...
Sep 20, 2011 |
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Researchers discover the mechanism that determines cell position in the intestinal epithelium
How do cells know where to position themselves and where to accumulate in order to carry out their functions correctly within each organ? Researchers with the Colorectal Cancer Lab at IRB Barcelona have revealed the molecular ...
Jul 31, 2011 |
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Click chemistry with copper -- a biocompatible version
Berkeley Lab researchers have found a way to make copper-catalyzed click chemistry biocompatible. By adding a ligand that minimizes the toxicity of copper but still allows it to catalyze the click chemistry ...
Jul 18, 2011 |
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Researchers closer to understanding cell-division gatekeeper enzyme
(PhysOrg.com) -- An enzyme called Pin1 regulates the protein that initiates cell division by changing the shape of a peptide bond. Researchers at Notre Dame and Virginia Tech have discovered how Pin1 communicates through ...
Jul 06, 2011 |
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Ligand
In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from covalent to ionic. Furthermore, the metal-ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands."
Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry.
Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). The size of a ligand is indicated by its cone angle.
For more information about Ligand, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
