News tagged with knockout mice
A mental retardation gene provides insights into brain formation (w/ Video)
(PhysOrg.com) -- Scientists at Duke University Medical Center have uncovered clues to memory and learning by exploring the function of a single gene that governs how neurons form new connections. The finding may also provide ...
Medicine & Health / Neuroscience
Feb 15, 2011 |
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Worm genes KO'd
Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing ...
Apr 25, 2010 |
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Muscle gene may provide new treatments for obesity and diabetes
(PhysOrg.com) -- Skeletal muscle enables us to walk, run or play a musical instrument, but it also plays a crucial role in controlling disease. Rockefeller University scientists have now shown how a specific molecule in skeletal ...
Jul 27, 2010 |
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Longer-lived, healthier mice offer promise of drug treatments for age-related diseases
Scientists have managed to extend the lifespan of mice by up to a fifth and reduce the number of age-related diseases the animals suffer. The research, which involved blocking a key molecular pathway, mimics ...
Medicine & Health / Medical research
Oct 01, 2009 |
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NEDD9 protein supports growth of aggressive breast cancer
Researchers at Fox Chase Cancer Center have demonstrated that a protein called NEDD9 may be required for some of the most aggressive forms of breast cancer to grow. Their findings, based on the study of a mouse model of breast ...
Oct 02, 2009 |
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Up a little on the left... now, over to the right... Scientists find a source of nonallergic itch
Scratching below the surface of a troublesome sensation that's equal parts tingle-tickle-prickle, sensory scientists from Johns Hopkins have discovered in mice a molecular basis for nonallergic itch.
Medicine & Health / Medical research
Dec 22, 2009 |
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Protein critical for insulin secretion may be contributor to diabetes
A cellular protein from a family involved in several human diseases is crucial for the proper production and release of insulin, new research has found, suggesting that the protein might play a role in diabetes.
Oct 26, 2009 |
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Genetically engineered mice yield clues to 'knocking out' cancer
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer. ...
Jul 01, 2009 |
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Researchers have immune cells running in circles
(PhysOrg.com) -- University of Illinois at Chicago College of Medicine researchers have identified the important role a protein plays in the body's first line of defense in directing immune cells called neutrophils toward ...
Medicine & Health / Medical research
Nov 02, 2009 |
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New insights into insulin resistance could lead to better drugs for diabetics
Research published in the October Molecular and Cellular Biology moves us closer to developing drugs that could mitigate diabetes.
Oct 21, 2011 |
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New genetic deafness syndrome identified
Ten years ago, scientists seeking to understand how a certain type of feature on a cell called an L-type calcium channel worked created a knockout mouse missing both copies of the CACNA1D gene.
Mar 09, 2011 |
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Study reveals capsaicin can act as cocarcinogen
The September cover story of the nation's leading cancer journal, Cancer Research, features a new study from The Hormel Institute, University of Minnesota, that links capsaicin, a component of chili peppers, to skin cancer ...
Sep 02, 2010 |
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Deleting ghrelin receptor, but not ghrelin, turns up fat-burning thermostat
Deleting the receptor, not the protein ghrelin itself, turns up the body's fat-burning thermostat, giving aging mice an exothermic boost toward a svelte physique, researchers reported at the American Society of Cell Biology's ...
Dec 13, 2010 |
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Gene knockout makes female mice masculine
The mammalian fucose mutarotase enzyme is known to be involved in incorporating the sugar fucose into protein. Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount them, and will attempt copulation ...
Jul 08, 2010 |
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Gene knockout may cheer up mice
Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect. Researchers writing in the open access journal BMC Neuroscience applied a battery of behavioral tests to the PKCI/HINT1 knocko ...
Medicine & Health / Neuroscience
Nov 12, 2009 |
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