News tagged with knockout mice

Highly efficient CRISPR knock-in in mouse

Genome editing using CRISPR/Cas system has enabled direct modification of the mouse genome in fertilized mouse eggs, leading to rapid, convenient, and efficient one-step production of knockout mice without ...

dateMay 01, 2015 in Biotechnology
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Fast track to mouse modeling

What genes are responsible for the development of breast cancer? What are the brain cell mutations that lead to the onset of Alzheimer's? To find new therapies, scientists have to understand how diseases ...

dateApr 02, 2013 in Biotechnology
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New genetic deafness syndrome identified

Ten years ago, scientists seeking to understand how a certain type of feature on a cell called an L-type calcium channel worked created a knockout mouse missing both copies of the CACNA1D gene.

dateMar 09, 2011 in Genetics
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Study reveals capsaicin can act as cocarcinogen

The September cover story of the nation's leading cancer journal, Cancer Research, features a new study from The Hormel Institute, University of Minnesota, that links capsaicin, a component of chili peppers, to skin cancer ...

dateSep 02, 2010 in Cancer
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Gene knockout makes female mice masculine

The mammalian fucose mutarotase enzyme is known to be involved in incorporating the sugar fucose into protein. Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount them, and will attempt copulation ...

dateJul 08, 2010 in Biotechnology
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Worm genes KO'd

Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing ...

dateApr 25, 2010 in Biotechnology
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Gene knockout may cheer up mice

Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect. Researchers writing in the open access journal BMC Neuroscience applied a battery of behavioral tests to the PKCI/HINT1 knocko ...

dateNov 12, 2009 in Neuroscience
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