News tagged with knockout mice

Fast track to mouse modeling

What genes are responsible for the development of breast cancer? What are the brain cell mutations that lead to the onset of Alzheimer's? To find new therapies, scientists have to understand how diseases ...

Apr 02, 2013
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New genetic deafness syndrome identified

Ten years ago, scientists seeking to understand how a certain type of feature on a cell called an L-type calcium channel worked created a knockout mouse missing both copies of the CACNA1D gene.

Mar 09, 2011
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Study reveals capsaicin can act as cocarcinogen

The September cover story of the nation's leading cancer journal, Cancer Research, features a new study from The Hormel Institute, University of Minnesota, that links capsaicin, a component of chili peppers, to skin cancer ...

Sep 02, 2010
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Gene knockout makes female mice masculine

The mammalian fucose mutarotase enzyme is known to be involved in incorporating the sugar fucose into protein. Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount them, and will attempt copulation ...

Jul 08, 2010
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Worm genes KO'd

Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing ...

Apr 25, 2010
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Gene knockout may cheer up mice

Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect. Researchers writing in the open access journal BMC Neuroscience applied a battery of behavioral tests to the PKCI/HINT1 knocko ...

Nov 12, 2009
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