News tagged with irinotecan
Irinotecan
Irinotecan (Camptosar, Pfizer; Campto, Yakult Honsha) is a drug used for the treatment of cancer.
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin.
Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan.
Irinotecan received accelerated approval by the U.S. Food and Drug Administration (FDA) in 1996 and full approval in 1998. During development, it was known as CPT-11.
For more information about Irinotecan, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
Conversion of brain tumor cells into blood vessels thwarts treatment efforts
Glioblastoma, the most common and lethal form of brain cancer and the disease that killed Massachusetts Senator Ted Kennedy, resists nearly all treatment efforts, even when attacked simultaneously on several ...
Jan 24, 2011 |
5 / 5 (7) |
1
|
Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
For the first time researchers have shown that by inhibiting the action of an enzyme called TAK-1, it is possible to make pancreatic cancer cells sensitive to chemotherapy, opening the way for the development of a new drug ...
Sep 24, 2009 |
4 / 5 (1) |
0
New treatments offer better survival and fresh challenges in colorectal cancer
Colorectal cancer (CRC) is the second leading cause of cancer-related death in the Western world. Fortunately physicians today have an abundance of drug therapies available to improve survival length for more advanced cancer ...
Aug 21, 2009 |
not rated yet |
0
Search results for irinotecan
GOLFIG increased progression-free survival in colorectal cancer patients
Oncologists can use colorectal cancer patients' own immune system to boost the effects of chemotherapy and increase progression-free survival, according to Phase III study results presented at the AACR 102nd Annual Meeting ...
Apr 06, 2011 |
not rated yet |
0
Discovery blocks cancer drug's toxic side effect
A debilitating side effect of a widely used but harshly potent treatment for colon cancer could be eliminated if a promising new laboratory discovery bears fruit.
Nov 04, 2010 |
4 / 5 (4) |
0
|
Cetuximab did not add significant benefit to NORDIC FLOX regimen in first line treatment of mCRC
Adding the targeted drug cetuximab to a three-drug chemotherapy regimen for first-line treatment of metastatic colorectal cancer does not improve response rate, progression-free survival or overall survival, researchers reported ...
Oct 12, 2010 |
4 / 5 (1) |
0
Lung cancer survival rates improved through use of individualized chemotherapy
Chemotherapy is the best broad defense against cancer recurrence after surgical resection. However, it is difficult to predict which patients will benefit from which regimen of anticancer drugs, if at all. Building on existing ...
Sep 01, 2010 |
not rated yet |
0
Chemotherapy resistance: Checkpoint protein provides armor against cancer drugs
Cell cycle checkpoints act like molecular tripwires for damaged cells, forcing them to pause and take stock. Leave the tripwire in place for too long, though, and cancer cells will press on regardless, making ...
Aug 27, 2009 |
not rated yet |
0
Genetic testing may be valuable in treating colorectal cancer
For the 29,000 patients in the United States with metastatic colorectal cancer, chemotherapy with irinotecan is a standard treatment that has been shown to improve survival. But for more than one in 10 of these patients, ...
Jul 27, 2009 |
not rated yet |
0
Pre-emptive treatment helped curtail skin toxicity with panitumumab
With a pre-emptive, prophylactic skin regimen, patients who receive panitumumab for treatment of metastatic colorectal cancer may be able to avoid some of the skin-associated toxicities, according to data presented at the ...
Jan 16, 2009 |
4 / 5 (1) |
0
Screening the herbal pharmacy
Curing cancer with natural products – a case for shamans and herb women? Not at all, for many chemotherapies to fight cancer applied in modern medicine are natural products or were developed on the basis of natural substances. ...
Mar 04, 2008 |
4.5 / 5 (4) |
0
Genetically modified cells attack tumors
St. Jude researchers show genetically modified stem cells in the nervous system actively seek out even tiny tumors Mice with neuroblastoma tumors have been successfully treated with genetically modified c ...
Dec 21, 2006 |
4.8 / 5 (23) |
0
List of search results for irinotecan
