The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been identified as mediating early splicing reactions in all introns of different lengths. However, Dr. Kazuhiro Fukumura in the Akila ...
Cell & Microbiology
Feb 14, 2024
0
3
To carry out all of life's functions, proteins must be produced from instructions carried by genes within DNA and delivered to the cell's protein-making machinery by messenger RNA.
Cell & Microbiology
Nov 24, 2023
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22
One of the most long-standing, fundamental mysteries of biology surrounds the poorly understood origins of introns. Introns are segments of noncoding DNA that must be removed from the genetic code before it is translated ...
Molecular & Computational biology
Nov 29, 2022
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1225
Johns Hopkins Medicine researchers say they have successfully used a cell's natural process for making proteins to "slide" genetic instructions into a cell and produce critical proteins missing from those cells. If further ...
Biotechnology
Oct 27, 2022
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50
Protein-coding genes carry the blueprint for protein production. In higher organisms, however, most of the coding-gene transcripts, or pre-mRNAs, are separated by non-coding sequences called "introns," which must be cut out ...
Molecular & Computational biology
Aug 13, 2021
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551
In an article published in the journal RNA, Karan Bedi, a bioinformatician in Mats Ljungman's lab, Department of Radiation Oncology at the University of Michigan Medical School, investigated the efficiency of splicing across ...
Biotechnology
Jul 9, 2021
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8
Scientists have discovered non-coding RNA has a novel role to fine-tune gene expressions during stress recovery, getting closer to uncovering a 30-year-old nuclear mystery.
Cell & Microbiology
Nov 29, 2019
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24
A new study led by scientists from the University of Colorado School of Medicine offers insight into the mechanism of a key cellular process.
Molecular & Computational biology
Sep 4, 2019
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82
Old-school Hollywood editors cut unwanted frames of film and patched in desired frames to make a movie. The human body does something similar—trillions of times per second—through a biochemical editing process called ...
Molecular & Computational biology
Jul 27, 2019
2
281
A research team from Whitehead Institute has uncovered a surprising and previously unrecognized role for introns, the parts of genes that lack the instructions for making proteins and are typically cut away and rapidly destroyed. ...
Cell & Microbiology
Jan 17, 2019
0
137
