A new study published in Cell Chemical Biology describes an alternative approach to treat diabetes by identifying drugs directly increasing the number of incretin-expressing cells. The work results from researchers at Karolinska ...
Biochemistry
Aug 23, 2022
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39
A living cell is exposed to a variety of stimuli. Countless messengers dock on its surface, where receptors in the cell membrane receive the incoming "orders." Signaling cascades are then triggered inside the cell, which ...
Cell & Microbiology
Mar 15, 2022
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49
In the field of drug development, frequent targets are cell-membrane proteins, such as ion channels, tiny pores that allow various substances to enter and exit the cell. Ion channels, which govern the passage of sodium, potassium, ...
Biochemistry
Sep 23, 2014
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0
Researchers at the Pediatric Diabetes Research Center (PDRC) at the University of California, San Diego School of Medicine have shown that the pancreatic protein Nkx6.1 – a beta-cell enriched transcription factor – is ...
Cell & Microbiology
Sep 12, 2013
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0
Researchers at the University of Texas Medical Branch at Galveston and the University of California-San Diego School of Medicine have published a study that offers a new understanding of a protein critical to physiological ...
Biochemistry
May 17, 2011
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0
Pancreatic β-cells are essential for secreting insulin to regulate glucose homeostasis. During metabolic stress they respond by increasing insulin production and secretion and proliferation to meet the increased metabolic ...
Cell & Microbiology
Sep 7, 2023
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10
Novel glucagon-like peptide-1 (GLP-1) drugs were designed and industrially prepared by researchers at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences through molecular design, strain construction, ...
Biochemistry
Sep 15, 2022
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43
The planet comprises continents and islands, each with unique cultures and resources. One area may be well known for growing food, another for manufacturing building materials, and yet despite their differences and distance ...
Molecular & Computational biology
Jan 7, 2021
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3
With the help of the CRISPR/Cas9 gene scissors, researchers at Lund University Diabetes Centre in Sweden have managed to "turn off" an enzyme that proved to play a key role in the regulation of the diabetes-associated TXNIP ...
Biochemistry
Dec 1, 2016
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25
The protein targets of a class of 'blockbuster' diabetes drugs have been identified by A*STAR researchers and may help explain varying type-2 patient responses to the drugs.
Biochemistry
Jan 6, 2016
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8
