A new study shows that the protein CHIP can regulate the insulin receptor more efficiently alone than in a paired state. In cellular stress situations, CHIP usually appears as a homodimer—an association of two identical ...
Cell & Microbiology
Sep 12, 2022
0
85
A team of scientists has created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin receptor, as well as vulnerable ...
Biochemistry
Mar 25, 2022
0
24
For millions of people with diabetes, insulin is essential medicine. But for some ocean-dwelling predators, insulin is a weapon. With a burst of venom, a fish-hunting cone snail can drop the blood sugar of its prey so precipitously ...
Biochemistry
Mar 15, 2022
0
359
A mother's response to stress can even influence her grandchildren.
Molecular & Computational biology
Oct 13, 2021
0
90
In a discovery that may further the understanding of diabetes and human longevity, scientists at Scripps Research have found a new biological mechanism of insulin signaling. Their study, involving the roundworm C. elegans, ...
Cell & Microbiology
Feb 25, 2020
0
203
As we are approaching the 100th anniversary of the discovery of insulin, a wide array of its signaling pathways has been defined. However, the initial step in insulin action, i.e. the engagement with its cell-surface receptor ...
Cell & Microbiology
Feb 20, 2018
0
7
Replacing a hydrogen atom by an iodine atom in insulin, the hormone retains its efficacy but is available more rapidly to the organism. Researchers at the University of Basel were able to predict this effect based on computer ...
Biochemistry
Jan 3, 2017
0
8
Each year, rice in Asia faces a big threat from a sesame seed-sized insect called the brown planthopper. Now, a study reveals the molecular switch that enables some planthoppers to develop short wings and others long—a ...
Plants & Animals
Mar 18, 2015
0
28
Since its landmark discovery in 1922, insulin has improved the health and extended the lives of more than 500 million people worldwide with diabetes mellitus. Yet the question of how this key hormone binds to its target cells ...
Biochemistry
Aug 4, 2014
0
0
One enzyme regulates the body's insulin receptor, ensuring energy needed for function and survival. The other enables a bacterium to wreak havoc in the form of bubonic plague.
Biochemistry
Aug 22, 2013
0
0
