To find out what activates SIRT6, the researchers alternately applied chemical inhibitors to human skin cells to determine which proteins were essential in getting the gene to repair the broken DNA strands. They discovered ...
Cell & Microbiology
Sep 9, 2016
0
714
Cancer cells are more dependent on a cellular garbage disposal unit—the proteasome—than healthy cells, and cancer therapies take advantage of this dependency. Scientists at EMBL and MPI determined the proteasome's 3D ...
Biochemistry
Aug 4, 2016
0
872
Reversible inhibition of an enzyme, an activity in which the inhibiting molecular entity (often a small chemical called ligand or inhibitor) associates and dissociates from the protein's binding site, is a very fast process. ...
Biochemistry
Apr 14, 2016
0
4
Infections with bacterium Clostridium difficile have rapidly become a significant medical problem in hospitals and long-term care facilities. The bacteria cause diarrhea and life-threatening inflammation of the colon by producing ...
Materials Science
Mar 25, 2016
0
120
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases, responsible for the degradation of the extracellular matrix (ECM). Their involvement has been demonstrated in several diseases, among which chronic inflammation ...
Biochemistry
Mar 15, 2016
0
5
Scientists have made a major breakthrough in the global search for a new drug to beat the malaria parasite's growing resistance to first-defence treatments.
Biochemistry
Feb 10, 2016
0
34
Doping in the horseracing industry has spurred regulations banning performance-enhancing drugs, as well as calls for an anti-doping agency in the U.S. But as in human sports, testing for certain kinds of prohibited substances ...
Analytical Chemistry
Jan 13, 2016
0
9
Protease inhibitors are a class of antiviral drugs that are commonly used to treat HIV, the virus that causes AIDS. Scientists at the University of Nebraska Medical Center designed a new delivery system for these drugs that, ...
Bio & Medicine
Oct 19, 2015
2
106
A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life-threatening diseases, including certain types of leukemia, lung cancer, kidney ...
Biochemistry
Sep 11, 2015
0
34
A group at the John Innes Centre has developed peas that will help animals absorb more protein from their diet. The study is published in PLOS ONE today.
Biotechnology
Aug 13, 2015
1
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