Crinkled coatings could prevent medical implants from failing

Medical implants could fail less often when coated with a microscopically crinkled, ceramic material designed by researchers at the University of Michigan. The coating is described in a paper published in ACS Applied Materials ...

The enemy within: How pathogens spread unrecognized in the body

Some pathogens hide inside human cells to enhance their survival. Researchers at the University of Basel, have uncovered a unique tactic certain bacteria use to spread in the body without being detected by the immune system. ...

Key protein regulates immune response to viruses in mammal cells

Researchers have revealed the regulatory mechanism of a specific protein that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help drive the development ...

Must mRNA be cloaked in a lipid coat to serve as a vaccine?

The Uchida Laboratory of Innovation Center of NanoMedicine has demonstrated that intradermal administration of mRNA alone (naked mRNA) without protection by nanoparticles induced robust vaccination against SARS CoV-2, a virus ...

Q&A: The engineer who delivers mRNA inside human cells

Messenger RNA became a household term when it was used as the backbone of the first COVID-19 vaccines, especially after the Nobel Prize was awarded to two mRNA pioneers at the University of Pennsylvania.

White blood cell

White blood cells (WBCs), or leukocytes (also spelled "leucocytes"), are cells of the immune system defending the body against both infectious disease and foreign materials. Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a hematopoietic stem cell. Leukocytes are found throughout the body, including the blood and lymphatic system.

The number of leukocytes in the blood is often an indicator of disease. There are normally between 4×109 and 1.1×1010 white blood cells in a litre of blood, making up approximately 1% of blood in a healthy adult. An increase in the number of leukocytes over the upper limits is called leukocytosis, and in leukopenia, this number is much lower than the lower limit. The physical properties of leukocytes, such as volume, conductivity, and granularity, may change due to activation, the presence of immature cells, or the presence of malignant leukocytes in leukemia.

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