Safeguarding genome integrity through extraordinary DNA repair

(PhysOrg.com) -- DNA is under constant attack, from internal factors like free radicals and external ones like ionizing radiation. About 10 double-strand breaks – the kind that snap both backbones of the double helix ...

New insights in the regulation of genetic information exchange

Within every cell in our body, our DNA is tightly bundled with proteins to form structures known as chromosomes. The commonly known shape of a chromosome relates to an X-shaped appearance in many organisms. The formation ...

Scientists unravel key steps in the road to DNA repair

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact ...

When editing bacteria with CRISPR, less is more

Systematically attenuating DNA targeting activity can achieve CRISPR-driven editing in bacteria, greatly boosting colony counts and even increasing the frequency of precise genome editing. This was shown in a study of the ...

E3 ubiquitin ligase plays essential role during rice meiosis

Synaptonemal complex (SC) assembly between paired homologous chromosomes plays a vital role in ensuring correct homologous recombination during meiosis. However, the mechanisms underlying the genetic regulation of SC assembly ...

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