New method to analyze nucleosomes

Northwestern Medicine scientists have developed a new method to analyze the protein composition of intact nucleosomes without losing combinatorial information present in chromatin. The technique, called Nuc-MS, could help ...

Screening for macrocyclic peptides

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, ...

Dewdrops on a spiderweb reveal the physics behind cell structures

As any cook knows, some liquids mix well with each other, but others do not. For example, when a tablespoon of vinegar is poured into water, a brief stir suffices to thoroughly combine the two liquids. However, a tablespoon ...

Big data kinase ohmics takes over drug discovery

In order for tumors to successfully take hold and spread in the body, they typically must meet several developmental milestones. These include things like suppressing apoptosis, cultivating replication and angiogenesis, weaning ...

Understanding COVID-19 infection and possible mutations

The binding of a SARS-CoV-2 virus surface protein spike—a projection from the spherical virus particle—to the human cell surface protein ACE2 is the first step to infection that may lead to COVID-19 disease. Penn State ...

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