Similarity of hepatocytes from liver and from stem cells improved

Research with stem cells is becoming increasingly important, because stem cells can develop into any body cell—skin cells, nerve cells or organ cells such as liver cells, the so-called hepatocytes. Stem cells can therefore ...

Scientists discover 'bulkheads' between liver cells

Researchers from Skoltech and their colleagues from Germany and the U.S. have discovered structures responsible for the shape of bile canaliculi, a network of canals in the liver. Published in the Journal of Cell Biology, ...

CRISPR-HOT: A new tool to 'color' specific genes and cells

Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs. They used this new method, called CRISPR-HOT, to investigate ...

3-D culturing hepatocytes on a liver-on-a-chip device

Liver-on-a-chip cell culture devices are attractive biomimetic models in drug discovery, toxicology and tissue engineering research. To maintain specific liver cell functions on a chip in the lab, adequate cell types and ...

Hepatocyte

A hepatocyte is a cell of the main tissue of the liver. Hepatocytes make up 70-80% of the liver's cytoplasmic mass. These cells are involved in:

The hepatocyte also initiates formation and secretion of bile.

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