The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal ...
May 23, 2013
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Circular RNAs were recently shown to be abundant in mice and humans where they influence gene expression.
May 22, 2013
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Mapping all of the chemical, or epigenetic, changes to chromosomes that affect which genes are turned on or off—and thus determine the fate of genomically identical cells in the body—usually requires ...
May 22, 2013
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Scientists have long known that control mechanisms known collectively as "epigenetics" play a critical role in human development, but they did not know precisely how alterations in this extra layer of biochemical instructions ...
May 09, 2013
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In biology, we often think of natural selection and survival of the fittest. What about survival of the luckiest? Like pioneers in search of a better life, bacteria on a surface wander around and often organize into highly ...
May 08, 2013
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RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics. In a study presented in the April 25 issue of the journal Cell, researchers from T ...
May 01, 2013
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(Phys.org)—A University of Michigan biophysical chemist and his colleagues have discovered the smallest and fastest-known molecular switches made of RNA, the chemical cousin of DNA. The researchers say ...
Oct 07, 2012
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Although thousands of entire genomes have been sequenced, our understanding of their detailed workings remains far from complete. Researchers continue to find new genes, determine their function, and map ...
May 10, 2013
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(Phys.org) —Proteins, the workhorses of the body, can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease.
Apr 29, 2013
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Berkeley Lab and UC Berkeley researchers have discovered that the transcription factor protein TFIID coexists in two distinct structural states, a key to genetic expression and TFIID's ability to initiate ...
Jan 17, 2013
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Current thinking on how the Toxoplasma gondii parasite invades its host is incorrect, according to a study published today in Nature Methods describing a new technique to knock out genes. The findings coul ...
Dec 23, 2012
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(Phys.org) —Changes in the bases that make up DNA act as markers, telling a cell which genes it should read and which it shouldn't. In the journal Angewandte Chemie, a British team has now introduced a new ...
Apr 25, 2013
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Long segments of RNA—encoded in our DNA but not translated into protein—are key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators ...
Feb 17, 2013
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A simplified version of an artificial cell produces functional proteins and even sorts them.
Mar 18, 2013
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