Understanding the family of cellular on/off switches known as G-proteins is important because these proteins control a lot of the communication between cells in the human body and beyond. A new study from the University of ...
Cell & Microbiology
Oct 21, 2022
0
2
A team of scientists led by the iHuman Institute of ShanghaiTech University has determined and analyzed the cryo-electron microscopy structures of human bitter taste receptor TAS2R46 complexed with G protein, in both strychnine-bound ...
Cell & Microbiology
Sep 15, 2022
1
22
A study published in Pharmacological Research reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids. ...
Biochemistry
Jul 22, 2022
0
18
Serotonin (5-HT) is one of the main neurotransmitters in the human central nervous system and peripheral nervous system. It helps regulate appetite, memory, cognition and mood through serotonin receptors (5-HTR).
Cell & Microbiology
Jun 17, 2022
0
473
Scientists at St. Jude Children's Research Hospital and Columbia University/New York State Psychiatric Institute are studying G protein-coupled receptors (GPCRs), membrane proteins that are the target of one-third of approved ...
Cell & Microbiology
Apr 27, 2022
0
24
G protein-coupled receptors (GPCRs) play a crucial role in cell signal transduction and comprise the largest drug target protein family. Despite recent breakthroughs in structural and pharmacological studies of these receptors, ...
Cell & Microbiology
Apr 20, 2022
0
65
In a structural analysis that could help inform efforts to develop new drugs for treating a myriad of diseases, RIKEN biologists have shed light on how the interaction between key signaling proteins and their regulatory partners ...
Cell & Microbiology
Mar 15, 2022
0
37
There are a number of G protein-coupled receptors in human cells. As an important component of the cell membrane, these proteins are responsible for detecting different stimuli in the surroundings of a cell within the body ...
Biochemistry
Oct 25, 2021
0
117
Cholecystokinin (CCK) and gastrin are the earliest discovered gastrointestinal hormones. They are the most abundant peptides in gastrointestinal tract and central nervous system, acting as physiologically important hormones ...
Biochemistry
Oct 8, 2021
0
28
A new optogenetic tool, a protein that can be controlled by light, has been characterized by researchers at Ruhr-Universität Bochum (RUB). They used an opsin—a protein that occurs in the brain and eyes—from zebrafish ...
Biotechnology
Jul 23, 2021
0
376
