Researchers suppress cell division in prostate tumour tissue through enzyme inhibition
A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme "soluble adenylyl ...
Researchers use SSRL to decipher structural details of deadly enzyme
(Phys.org)—A small team of researchers has used the brilliant X-rays of the Stanford Synchrotron Radiation Laboratory to pin down the crystalline structure of an enzyme complex that scientists had spent ...
Scientists show protein-making machinery can switch gears with a small structural change process
For the past several years, Min Guo, an assistant professor at The Scripps Research Institute, has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process ...
Location, location, location: Membrane 'residence' gives proteases novel abilities
Johns Hopkins scientists have discovered a new mode of action for enzymes immersed in cellular membranes. Their experiments suggest that instead of recognizing and clipping proteins based on sequences of ...
Algae can draw energy from other plants
Flowers need water and light to grow. Even children learn that plants use sunlight to gather energy from earth and water. Members of Professor Dr. Olaf Kruse's biological research team at Bielefeld University ...
X-ray laser helps fight sleeping sickness: Exploiting parasite's weak spot may lead to new treatments
An international group of scientists working at the SLAC National Accelerator Laboratory has mapped a weak spot in the parasite that causes African sleeping sickness, pinpointing a promising new target for ...
Waste removal in worms reveals new mechanism to regulate calcium signaling
Calcium is so much more than the mineral that makes our bones and teeth strong: It is a ubiquitous signaling molecule that provides crucial information inside of and between cells. Calcium is used to help ...
Plants cut the mustard for basic discoveries in metabolism
You might think you have nothing in common with mustard except hotdogs. Yet based on research in a plant from the mustard family, Salk scientists have discovered a possible explanation for how organisms, ...
The search for new antibiotics: Tiny proteins prevent bacterial gene transcription
(Phys.org) —In the search for new antibiotics, researchers are taking an unusual approach: They are developing peptides, short chains of protein building blocks that effectively inhibit a key enzyme of ...
New anti-inflammatory drugs pinch off reactive oxygen species at the source
Scientists at Emory University School of Medicine have identified a new type of anti-inflammatory compound that may be useful in treating a wide range of conditions, including neurodegenerative and autoimmune diseases. These ...
Development of the first way to make large amounts of promising anti-cancer substance
Scientists are reporting development of the first practical way to make large amounts of a promising new anti-cancer substance that kills cancer cells differently than existing medicines. Their article on ...
Random walks on DNA
Scientists have revealed how a bacterial enzyme has evolved an energy-efficient method to move long distances along DNA. The findings, published in Science, present further insight into the coupling of chemical and mechan ...
1960s-era anti-cancer drug points to treatments for Lou Gehrig's disease
A long-used anti-cancer drug could be a starting point to develop new treatments for the incurable nerve disease known as Lou Gehrig's disease or amyotrophic lateral sclerosis (ALS), scientists are reporting. ...
Drink made from berry wine may provide tasty drug for diabetes
In evaluating the bioactive compounds of Illinois blueberry and blackberry wines, University of Illinois scientists have found compounds that inhibit enzymes responsible for carbohydrate absorption and assimilation. And that ...