Locating and severing lethal links in DNA

Chemical lesions in the genetic material DNA can have catastrophic consequences for cells, and even for the organism concerned. This explains why the efficient identification and rapid repair of DNA damage is vital for survival. ...

Researchers take a fresh look at the Michaelis-Menten equation

Researchers from Aarhus University challenge one of the cornerstones of biochemistry, the Michaelis-Menten equation. They show that many enzymes in signaling pathways are independent of substrate concentration, because the ...

Small enzyme-mimicking polymers may have helped start life

Most effort in origins of life research is focused on understanding the prebiotic formation of biological building blocks. However, it is possible early biological evolution relied on different chemical structures and processes, ...

X-rays size up protein structure at the 'heart' of COVID-19 virus

A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease—the enzyme that enables the virus ...

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