Johns Hopkins scientists have discovered a new mode of action for enzymes immersed in cellular membranes. Their experiments suggest that instead of recognizing and clipping proteins based on sequences of ...
Nov 16, 2012
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A new study by researchers at Imperial College London has identified a way in which Salmonella bacteria, which cause gastroenteritis and typhoid fever, counteract the defence mechanisms of human cells.
Nov 15, 2012
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For the past several years, Min Guo, an assistant professor at The Scripps Research Institute, has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process ...
Nov 15, 2012
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Researchers at the University of Dundee have uncovered the mechanism of an important human enzyme that plays a role in the development of debilitating diseases including cancer, dementia and diabetes.
Oct 30, 2012
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The glowing green molecule known as green fluorescent protein (GFP) has revolutionized molecular biology. When GFP is attached to a particular protein inside a cell, scientists can easily identify and locate ...
Oct 22, 2012
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Pathogenic bacteria bristle with surface proteins that help them to infect their host. From chemical hooks that anchor the bacteria in place to cloaking proteins that hide them from their host's immune system, ...
Oct 12, 2012
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One can often begin to understand a protein's function by identifying its accomplices in the cell. Accordingly, scientists have developed diverse biochemical assays that essentially allow them to go 'fishing' ...
Oct 10, 2012
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The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria ...
Oct 09, 2012
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Open an undergraduate biochemistry textbook and you will learn that enzymes are highly efficient and specific in catalyzing chemical reactions in living organisms, and that they evolved to this state from ...
Aug 30, 2012
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Two opposing teams battle it out to regulate gene expression on the DNA playing field. One, the activators, keeps DNA open to enzymes that transcribe DNA into RNA. Their repressor opponents antagonize that ...
Aug 26, 2012
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I have been teaching and doing research at the university level for more than 40 years, which means that for more than four decades, I have been participating in a deception - benevolent and well intentioned, to be sure, ...
Aug 17, 2012
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Researchers for the first time have shown that members of a family of enzymes known as cathepsins – which are implicated in many disease processes – may attack one another instead of the bodily ...
Aug 13, 2012
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In an advance that could be used in masks to protect against nerve gas, scientists are reporting development of proteins that are up to 15,000 times more effective than their natural counterpart in destroying ...
Aug 08, 2012
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Next week's Journal of Biological Chemistry "Paper of the Week" by Wai Mun Huang and colleagues at the University of Utah Health Sciences Center and the University of Minnesota reveals new insights into the molecular proper ...
Jul 11, 2012
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German scientists have applied a new method -- "inverse Partial Fluorescence Yield" (iPFY) on micro-jet -- which will enable them to probe the electronic structure of liquids free of sample damages. The experiments ...
Jul 06, 2012
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