Researchers have discovered ways to convert inhibitor-style targeted cancer drugs into small molecules known as degraders, which help destroy cancer-promoting proteins in cells.
Biochemistry
Apr 11, 2024
0
34
In a new breakthrough that could revolutionize medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.
Polymers
Apr 10, 2024
0
15
A new study led by Prof. Meital Reches of the Hebrew University with Mr. Daniel Boas, a Ph.D. student in her group and team of collaborators, has pioneered a new drug delivery system centered on switchable peptide-stabilized ...
Biochemistry
Apr 9, 2024
0
35
Since the 1970s, modern antibiotic discovery has been experiencing a lull. Now the World Health Organization has declared the antimicrobial resistance crisis as one of the top 10 global public health threats.
Cell & Microbiology
Apr 8, 2024
0
48
A new automated workflow developed by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) has the potential to allow researchers to analyze the products of their reaction experiments in real time, a key capability ...
Analytical Chemistry
Apr 8, 2024
0
42
A nanosized polymer, developed by a research team from Ben-Gurion University of the Negev, can selectively deliver chemotherapeutic drugs to blood vessels that feed tumors and metastases and has emerged as an effective treatment ...
Bio & Medicine
Apr 8, 2024
0
72
The active ingredient in many drugs is what's known as a small molecule: bigger than water, much smaller than an antibody and mainly made of carbon. It's tough, however, to make these molecules if they require a quaternary ...
Materials Science
Apr 6, 2024
4
81
New research could pave the way to developing cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death. Cancer cells that are resistant to anticancer drugs are known to be vulnerable to ferroptosis. ...
Biotechnology
Apr 5, 2024
0
50
Cold Spring Harbor Laboratory (CSHL) chemists have created a new collection of molecular compounds and begun testing them as potential leads in the search for new drugs. Among these molecules, they found several that show ...
Analytical Chemistry
Apr 4, 2024
0
85
The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive activation and cytokine-independent ...
Molecular & Computational biology
Apr 4, 2024
0
16
