News tagged with drug targets
3D structure opens new avenue for drug discovery
(PhysOrg.com) -- An international consortium has determined the structure of an important new drug target in complex with a synthetic molecule designed by our researchers, opening up new avenues for drug discovery.
Apr 02, 2012 |
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Scientists create potent molecules aimed at treating muscular dystrophy
While RNA is an appealing drug target, small molecules that can actually affect its function have rarely been found. But now scientists from the Florida campus of The Scripps Research Institute have for the first time designed ...
Feb 22, 2012 |
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Immunoproteasome crystal structure determined
Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively ...
Feb 16, 2012 |
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Preventing bacteria from falling in with the wrong crowd could help stop gum disease
Stripping some mouth bacteria of their access key to gangs of other pathogenic oral bacteria could help prevent gum disease and tooth loss. The study, published in the journal Microbiology suggests that t ...
Feb 08, 2012 |
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Chemists unlock potential target for drug development
A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University ...
Chemistry / Analytical Chemistry
Jan 19, 2012 |
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Genetic code cracked for a devastating blood parasite
(PhysOrg.com) -- Scientists have cracked the genetic code and predicted some high priority drug targets for the blood parasite Schistosoma haematobium, which is linked to bladder cancer and HIV/ AIDS and causes the insidious ...
Jan 18, 2012 |
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Scientists characterize protein essential to survival of malaria parasite
A biology lab at Washington University has just cracked the structure and function of a protein that plays a key role in the life of a parasite that killed 655,000 people in 2010.
Jan 06, 2012 |
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How fruit flies can teach us about curing chronic pain and halting mosquito-borne diseases
Studies of a protein that fruit flies use to sense heat and chemicals may someday provide solutions to human pain and the control of disease-spreading mosquitoes.
Dec 06, 2011 |
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Four new leads identified for anti-cancer drugs
Four new anti-cancer drug leads have been identified in a research paper published online this week in Bioorganic and Medicinal Chemistry.
Nov 28, 2011 |
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Scientists uncover new role for gene in maintaining steady weight
Against the backdrop of the growing epidemic of obesity in the United States, scientists from the Florida campus of The Scripps Research Institute have made an important new discovery regarding a specific gene that plays ...
Nov 23, 2011 |
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Cancer drug cisplatin found to bind like glue in cellular RNA
An anti-cancer drug used extensively in chemotherapy binds pervasively to RNA -- up to 20-fold more than it does to DNA, a surprise finding that suggests new targeting approaches might be useful, according to University of ...
Nov 21, 2011 |
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Tuberculosis researchers discover potential new target for treatments
(PhysOrg.com) -- Colorado State University researchers have discovered an enzyme that is critical to the survival and replication of the bacterial pathogen that causes tuberculosis. The enzyme may become a key target for ...
Nov 21, 2011 |
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X-rays help advance the battle against heart disease
(PhysOrg.com) -- Scientists from Imperial College London and Diamond Light Source have revealed the structure of a cholesterol-lowering-drug target. Published in the journal Nature, this finding could lead ...
Oct 06, 2011 |
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Combating mood disorders: New approach simplifies the search for more specific drugs
Many psychiatric conditions are caused by aberrant metabolism of the neurotransmitter serotonin. Researchers in the Department of Pharmacy at LMU have now developed a new screening method, which will facilitate the search ...
Sep 30, 2011 |
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Nanoparticles working in harmony
For decades, researchers have been working to develop nanoparticles that deliver cancer drugs directly to tumors, minimizing the toxic side effects of chemotherapy. However, even with the best of these nanoparticles, only ...
Nanotechnology / Bio & Medicine
Jul 15, 2011 |
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