A detailed atomic exploration into how the dengue virus replicates its genome could catalyze the development of high-precision targeted antiviral therapeutics.
Cell & Microbiology
Oct 31, 2023
0
1
A widely used screening tool deployed in the early phases of drug discovery to weed out undesirable compounds is wrong so often it can't be trusted on its own, according to scientists at the University of North Carolina at ...
Biochemistry
Jul 11, 2017
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2
Two researchers from Skoltech and McGill University have published a review of the promising research field known as structural proteomics in the journal Chemical Reviews. This field combines protein chemistry and mass spectrometry, ...
Biochemistry
Jan 27, 2022
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57
When a human consumes a pharmaceutical drug, enzymes in the liver break down the substance into metabolites that are water soluble, so the body can more easily excrete them. In some cases, the resulting metabolites may have ...
Biochemistry
Jul 13, 2023
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9
Defensive compounds produced by microbes are a major source of antibiotics and other important medicines. But with resistant bugs appearing faster than potential allies, researchers are taking their search for drug candidates ...
Cell & Microbiology
Apr 9, 2019
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10
A new paper on cybervetting says that organizations need to develop and implement clearly defined rules regarding how they use online information about job candidates. Failing to better regulate their use of cybervetting ...
Social Sciences
Sep 13, 2022
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17
Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug-like molecules and the amino acids of proteins vary so much in their chemistry. ...
Biochemistry
Apr 21, 2014
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0
A research team at the VIB-KU Leuven Center for Microbiology and the KU Leuven Department of Biology showed that, contrary to generally held belief, most components of essential oils could meet the criteria set for drug candidates. ...
Analytical Chemistry
Feb 21, 2020
3
3
Using an unconventional approach that they designed, University of Pittsburgh drug discoverers and their collaborators at Walter Reed Army Institute of Research have identified compounds that hold promise for treating leishmaniasis, ...
Biochemistry
Nov 3, 2009
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0
(Phys.org) -- Many drug candidates fail because of low solubility or poor pharmacokinetic behavior. Ron Raines and colleagues at the University of Wisconsin–Madison (USA) have devised a new prodrug strategy to overcome ...
Biochemistry
Aug 6, 2012
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