Chemists have long believed that inserting nitrogen—a beneficial ingredient for making many pharmaceuticals and other biologically active molecules—into a carbon-hydrogen bond requires a trade-off between catalyst reactivity ...
Materials Science
Oct 15, 2015
0
466
Aryl alkyl ethers are important structural motifs found in many biologically active compounds. Therefore, stereoselective etherification is a highly important synthetic operation in the preparation of drug candidates. However, ...
Biochemistry
Sep 15, 2015
0
20
A new study from scientists at The Scripps Research Institute (TSRI) explores a bacterial enzyme that might be used as a drug candidate to help people quit smoking. The research shows that this enzyme can be recreated in ...
Biochemistry
Aug 6, 2015
1
858
Using DESY's ultra bright X-ray source PETRA III, scientists have resolved the molecular structure of two promising drug candidates from the new group of Spiegelmers for the first time. The results provide a deeper understanding ...
Biochemistry
Apr 22, 2015
0
17
In the first experimental use of algorithms that employ structure-based molecular modeling to optimize deimmunized drug candidates, Karl Griswold, PhD, and co-investigator Christopher Bailey-Kellogg, PhD of Dartmouth College ...
Biotechnology
Feb 13, 2015
0
431
Officials at a life sciences startup based on a Purdue University innovation say their technology could help pharmaceutical companies find more effective drug candidates and improve the results of personalized cancer care.
Analytical Chemistry
Nov 5, 2014
0
0
Biting into a chili pepper causes a burning spiciness that is irresistible to some, but intolerable to others. Scientists exploring the chili pepper's effect are using their findings to develop a new drug candidate for many ...
Biochemistry
Aug 20, 2014
0
0
Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug-like molecules and the amino acids of proteins vary so much in their chemistry. ...
Biochemistry
Apr 21, 2014
0
0
Chemists at The Scripps Research Institute (TSRI) have devised a greatly improved technique for making amino acids not found in nature. These "unnatural" amino acids traditionally have been very difficult to synthesize, but ...
Biochemistry
Mar 13, 2014
0
0
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have described a pair of drug candidates that advance the search for new treatments for pain, addiction and other disorders.
Biochemistry
Jan 13, 2014
0
0
