Identifying the optimal drug treatment is like hitting a moving target. To stop disease, small-molecule drugs bind tightly to an important protein, blocking its effects in the body. Even approved drugs don't usually work ...
Biochemistry
May 20, 2019
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7
Defensive compounds produced by microbes are a major source of antibiotics and other important medicines. But with resistant bugs appearing faster than potential allies, researchers are taking their search for drug candidates ...
Cell & Microbiology
Apr 9, 2019
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10
Searching for new drugs is like fishing in the dark: the prospect of catching something is very uncertain, and it requires patience, skill and – of course – money. ETH researchers led by Dario Neri have developed a new ...
Biochemistry
Mar 28, 2018
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12
McMaster University engineers have devised a way to make testing for new drugs more efficient and affordable, and reduce the time for helpful medications to reach the public.
Biochemistry
Feb 9, 2018
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7
Scientists at DESY have developed a new method that enables automated and fast screening of promising drug candidates. This novel technique, called mix-and-diffuse serial synchrotron crystallography, can image the interaction ...
Biochemistry
Dec 8, 2017
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3
A widely used screening tool deployed in the early phases of drug discovery to weed out undesirable compounds is wrong so often it can't be trusted on its own, according to scientists at the University of North Carolina at ...
Biochemistry
Jul 11, 2017
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2
Drug discovery may bring to mind images of white lab coats and pipettes, but when Henry Lin, PhD, recently set out to find a better opioid with fewer side effects, his first step was to fire up the computers.
Biochemistry
Apr 6, 2017
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9
Aryl alkyl ethers are important structural motifs found in many biologically active compounds. Therefore, stereoselective etherification is a highly important synthetic operation in the preparation of drug candidates. However, ...
Biochemistry
Sep 15, 2015
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20
Using DESY's ultra bright X-ray source PETRA III, scientists have resolved the molecular structure of two promising drug candidates from the new group of Spiegelmers for the first time. The results provide a deeper understanding ...
Biochemistry
Apr 22, 2015
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17
Officials at a life sciences startup based on a Purdue University innovation say their technology could help pharmaceutical companies find more effective drug candidates and improve the results of personalized cancer care.
Analytical Chemistry
Nov 5, 2014
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