New insight into proteins called "pioneer factors" helps to explain their unusual ability to open up the typically dense genetic material within our cells. This behavior makes the genetic material accessible for proteins ...
Cell & Microbiology
Apr 20, 2023
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20
DNA replication is the process whereby cells make an exact copy of their DNA before cell division. A key part of the intricate DNA replication machinery is a molecular motor called CMG, which has the vital task of separating ...
Biotechnology
Apr 20, 2023
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242
The DNA molecule is located in the cell nucleus as a densely packed complex of DNA and protein, known as chromatin. Wrapped in sections around a core of special proteins known as histones, the DNA forms so-called nucleosomes, ...
Cell & Microbiology
Apr 6, 2023
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41
Throughout our lives, a small pool of hematopoietic stem/progenitor cells (HSPCs) ensures the stable production of a wide range of blood and immune cells in our bodies. RIKEN researchers have now discovered how these cells ...
Cell & Microbiology
Mar 14, 2023
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10
Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN) with microscopy images of ...
Biotechnology
Mar 13, 2023
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187
As time passes and we get older, many cells need to replenish themselves. They do so by dividing into new cells: Heart cells, skin cells and so on.
Cell & Microbiology
Feb 13, 2023
0
106
In all living organisms, DNA replication is essential to ensure the genetic fidelity of the next generation. However, bacteria can also transfer genetic information horizontally to other bacteria. Many species of pathogenic ...
Cell & Microbiology
Feb 3, 2023
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8
Researchers at Umeå University have discovered how a certain type of protein moves for DNA to be copied. The discovery could have implications for understanding how antibiotic resistance genes spread between bacteria.
Cell & Microbiology
Jan 27, 2023
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78
Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome—a cell's complete set of DNA—is most vulnerable while it is being duplicated before a cell divides. Cancer ...
Cell & Microbiology
Jan 24, 2023
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10
A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers. The work, published Jan. 5 in Molecular Cell, ...
Cell & Microbiology
Jan 24, 2023
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