Discovering new drugs, inspired by Darwinian theory

The body must constantly defend itself against bacteria and viruses. It generates millions of different antibodies, which are selected to recognize the enemy and trigger the best possible immune response. Scientists use these ...

High-resolution mapping method for G4 DNA structures developed

While investigating the unusual G quadruplex DNA structure (G4), the Simon Elsässer group has developed a more accurate method for mapping these structures in the genome. G4 CUT&Tag revealed numerous G4s in the human and ...

The role of messenger RNA in DNA repair

An organism's genome could be compared to a complex system of instructions that allows it not only to develop, but also to carry out all the activities essential to its survival. To do this, this genome needs to be expressed ...

Neutrons take a deep dive into water networks surrounding DNA

Water plays several important roles within the human body, even affecting the DNA in our cells. The entire surface of a DNA double helix is coated in layers of water molecules. This sheath of water attaches to the genetic ...

Non-invasive DNA-labeling tool opens doors for new research

Dutch researchers have developed a new tool to label DNA for studying chromosomes in live cells. The tool is non-invasive and can be applied in culture but also in living organisms, such as zebrafish embryos. The team published ...

New methods for detecting single molecules

Resistance to antibiotics is on the rise worldwide. Researchers at the Fraunhofer Institute for Physical Measurement Techniques IPM alongside the Ludwig Maximilian University of Munich have developed a process for rapidly ...

Effect of small polyanions on retroviruses

A retrovirus is a virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing that cell's genome. Once inside the host cell's cytoplasm, the virus uses its reverse transcriptase enzyme ...

Superselective colloid-surface binding visualized

Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cell membranes. This allows for selectivity and also reversibility—the binding can also be undone. ...

In situ extraction and detection of DNA using nanopores

Being able to detect DNA from a single cell is important for the detection of diseases and genetic disorders. Measuring single DNA molecules has been possible for some time; however, directly detecting samples at the point ...

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