New tool probes gene regulation

DNA methylation (DNAme) is a modification of the genome—an epigenetic "mark"—that is required for proper cellular differentiation. It has been implicated in the regulation of gene expression, but its role in this stepwise ...

'Living fossil' may upend basic tenet of evolutionary theory

The field of evolutionary biology has seen its share of spirited debates. But if there's one principle that virtually every expert in the field agrees on, it's that natural selection occurs at the level of the genome.

Study: The human lifespan is written into our DNA

Humans have a "natural" lifespan of around 38 years, according to a new method we have developed for estimating the lifespans of different species by analyzing their DNA.

Method to customize microbes for better biofuel production

Scientists at the US Department of Energy's Oak Ridge National Laboratory have demonstrated a method to insert genes into a variety of microorganisms that previously would not accept foreign DNA, with the goal of creating ...

Scientists uncover mystery of DNA methylation

All species mark their DNA with methyl groups. This is done to regulate gene expression, distinguish indigenous DNA from foreign DNA, or to mark old DNA strands during replication. Methylation is carried out by certain enzymes ...

Pinpointing the molecular mechanisms of ageing

Although each and every one of us goes through it, ageing is a poorly understood process. Researchers have used a biomarker called the epigenetic clock to identify a gene that is closely linked to ageing in humans. The study, ...

Researchers explain signals of CpG 'traffic lights' in DNA

A research team featuring bioinformaticians from the Moscow Institute of Physics and Technology (MIPT) has identified reliable markers of gene activity. The discovery has potential for future applications in clinical practice. ...

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