In this week's issue of Science Signaling (22 January, 2013), Danen and colleagues of the Division of Toxicology of LACDR report novel insights into the question how stem cells decide to commit suicide when their DNA is damaged.
Cell & Microbiology
Jan 23, 2013
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DNA damage occurs in all cellular organisms. In human cells, it can be caused by the body's normal metabolic activities, by environmental factors or by chemotherapy. During the crucial phase when cells replicate their genetic ...
Cell & Microbiology
Mar 11, 2019
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Earth's atmosphere shields life on the ground from cosmic radiation that can damage DNA. Astronauts in space have no such protection, and that puts them at risk. An investigation on the International Space Station examines ...
Space Exploration
May 9, 2019
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A team of researchers from the biology department at TU Darmstadt has discovered that the processes for repairing DNA damage are far more complex than previously assumed. The ends of breaks in the double helix are not just ...
Cell & Microbiology
Feb 2, 2017
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It's estimated that there are approximately 80,000 industrial chemicals currently in use, in products such as clothing, cleaning solutions, carpets, and furniture. For the vast majority of these chemicals, scientists have ...
Biochemistry
Dec 17, 2019
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(PhysOrg.com) -- After more than a century of technological refinements, zippers still get stuck. So do the molecular machines that routinely unzip the double helix of DNA in our cells after billions of years of evolution, ...
Cell & Microbiology
Jul 21, 2010
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Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...
Biochemistry
Mar 1, 2012
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Researchers in Freiburg identify a protein responsible for the correct arrangement of the chromosome centromeres in the nucleus.
Cell & Microbiology
Apr 4, 2013
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A protein that helps embryonic stem cells (ESCs) retain their identity also promotes DNA repair, according to a study in The Journal of Cell Biology. The findings raise the possibility that the protein, Sall4, performs a ...
Cell & Microbiology
Mar 2, 2015
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Large molecular motors consisting of up to a dozen different proteins regulate access to the genome, which is essential for the transcription of genes and for the repair of DNA damage. Susan Gasser and her team now reveal ...
Cell & Microbiology
Aug 28, 2014
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