News tagged with disc1
DISC1
Disrupted in schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research.
For more information about DISC1, read the full article at
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New study solidifies role of DISC1 in risk for schizophrenia and other mental illness
Johns Hopkins researchers report the discovery of a molecular switch that regulates the behavior of a protein that, when altered, is already known to increase human susceptibility to schizophrenia and mood disorders.
Apr 06, 2011 |
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Before or after birth, gene linked to mental health has different effects
Scientists have long eyed mutations in a gene known as DISC1 as a possible contributor to schizophrenia and mood disorders, including depression and bipolar disorder. Now, new research led by Johns Hopkins researchers suggests ...
Medicine & Health / Psychology & Psychiatry
Jan 05, 2010 |
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New 'schizophrenia gene' prompts researchers to test potential drug target
Johns Hopkins scientists report having used a commercially available drug to successfully "rescue" animal brain cells that they had intentionally damaged by manipulating a newly discovered gene that links susceptibility genes ...
Medicine & Health / Neuroscience
Oct 27, 2009 |
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A genetic basis for schizophrenia
Schizophrenia is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment ...
Jul 21, 2009 |
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Genetic clues hold key to schizophrenia treatment
Researchers have taken a step forward in understanding the genetics of mental illnesses such as schizophrenia and bipolar disorder.
Mar 20, 2009 |
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Schizophrenia-linked gene controls the birth of new neurons
A gene that is arguably the most studied "schizophrenia gene" plays an unanticipated role in the brain: It controls the birth of new neurons in addition to their integration into existing brain circuitry, according to a report ...
Mar 19, 2009 |
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