Massive fragment screen points way to new SARS-CoV-2 inhibitors

New research published in Science Advances provides a template for how to develop directly acting antivirals with novel modes of action that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused ...

Anticancer compound found in monsoon-season delicacy

A small-branched shrub found in India known locally as Moddu Soppu (Justicia wynaadensis) is used to make a sweet dish during the monsoon season by the inhabitants of Kodagu district in Karanataka exclusively during the monsoons. ...

Molecular simulations show how drugs block key receptors

Many pharmaceuticals work by targeting what are known as 'G-protein-coupled receptors.' In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used ...

Viewing dopamine receptors in their native habitat

Dopamine, a chemical that sends messages between different parts of the brain and body, plays a key role in a variety of diseases and behaviors by interacting with receptors on cells. But despite their importance in physiology ...

Hidden symmetry found in chemical kinetic equations

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

Engineers model mutations causing drug resistance

Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and "second generation" approaches are needed. ...

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