Microneedles for therapeutic gene delivery

There is great potential in gene therapy for treating certain types of cancer and genetic defects, immunological diseases, wounds and infections. The therapies work by delivering genes into the patients' cells, which then ...

Editing immune response could make gene therapy more effective

Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing ...

Becoming a nerve cell: Timing is of the essence

Mitochondria are small organelles that provide the energy critical for each cell in our body, in particular, in the energy-demanding brain. In this week's edition of Science, a Belgian team of researchers led by Pierre Vanderhaeghen ...

Eggshell-based surgical material for skull injuries

A bioactive polymer-ceramic composite for fixing implants and restoring bone defects in the skull was developed by an international group of materials scientists from the NUST MISIS Center for Composite Materials. An innovative ...

How mutant zebrafish helped unlock the secret to their stripes

Zebrafish are one of the most well studied animals on the planet. But how they came by their beautiful black and gold stripes is more of a mystery. Our new research used mathematical modeling—and detailed observations of ...

Mystery about cause of genetic disease in horses

Warmblood fragile foal syndrome is a severe, usually fatal, genetic disease that manifests itself after birth in affected horses. Due to the defect, the connective tissue is unstable. Under force, for instance, the skin tears ...

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