News tagged with damaged proteins
Do bacteria age? Biologists discover the answer follows simple economics
When a bacterial cell divides into two daughter cells and those two cells divide into four more daughters, then 8, then 16 and so on, the result, biologists have long assumed, is an eternally youthful population of bacteria. ...
Oct 27, 2011 |
4.9 / 5 (30) |
15
|
Key protein aids in DNA repair
Scientists have shown in multiple contexts that DNA damage over our lifetimes is a key mechanism behind the development of cancer and other age-related diseases. Not everyone gets these diseases, because the body has multiple ...
Apr 11, 2010 |
4.5 / 5 (20) |
2
|
Scientists show TAp63 suppresses cancer metastasis
Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs, researchers at The University of Texas MD Anderson Cancer Center ...
Oct 20, 2010 |
5 / 5 (4) |
0
|
Mapping of protein inhibitors facilitates development of tailor-made anticancer agents
(PhysOrg.com) -- A team of researchers at Karolinska Institutet in Sweden has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism ...
Feb 20, 2012 |
5 / 5 (3) |
0
|
Chromosome 'glue' surprises scientists
Proteins called cohesins ensure that newly copied chromosomes bind together, separate correctly during cell division, and are repaired efficiently after DNA damage. Scientists at the Carnegie Institution have found for the ...
May 06, 2010 |
5 / 5 (7) |
0
|
Loss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise, Study Finds
(PhysOrg.com) -- A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrup ...
Oct 15, 2009 |
5 / 5 (1) |
0
Scientists identify novel approach to view inner workings of viruses
Since the discovery of the microscope, scientists have tried to visualize smaller and smaller structures to provide insights into the inner workings of human cells, bacteria and viruses. Now, researchers at the National Institute ...
Jan 12, 2012 |
4 / 5 (5) |
0
|
A chaperone for the 'guardian of the genome'
The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...
Sep 07, 2011 |
5 / 5 (3) |
0
|
Mystery solved: Tiny protein-activator responsible for brain cell damage in Huntington disease
Johns Hopkins brain scientists have figured out why a faulty protein accumulates in cells everywhere in the bodies of people with Huntington's disease (HD), but only kills cells in the part of the brain that controls movement, ...
Medicine & Health / Medical research
Jun 04, 2009 |
5 / 5 (10) |
0
An Alzheimer's vaccine in a nasal spray
One in eight Americans will fall prey to Alzheimer's disease at some point in their life, current statistics say. Because Alzheimer's is associated with vascular damage in the brain, many of them will succumb through a painful ...
Medicine & Health / Medical research
Feb 28, 2011 |
5 / 5 (10) |
3
|
Protein and microRNA block cellular transition vital to metastasis
Like a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state, researchers report online at Nature Cell Bi ...
Feb 25, 2011 |
4.8 / 5 (4) |
0
|
Study identifies a key molecular switch for telomere extension by telomerase
Researchers at the University of Illinois at Chicago College of Medicine describe for the first time a key target of DNA damage checkpoint enzymes that must be chemically modified to enable stable maintenance of chromosome ...
Nov 23, 2011 |
5 / 5 (5) |
1
|
How old yeast cells send off their daughter cells without the baggage of old age
The accumulation of damaged protein is a hallmark of aging that not even the humble baker's yeast can escape. Yet, aged yeast cells spawn off youthful daughter cells without any of the telltale protein clumps. ...
Nov 23, 2011 |
5 / 5 (1) |
0
|
Chaperone enzyme provides new target for cancer treatments
UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads ...
Jan 18, 2011 |
5 / 5 (2) |
0
|
Researchers pinpoint how one cancer gene functions
For several decades, researchers have been linking genetic mutations to diseases ranging from cancer to developmental abnormalities. What hasn't been clear, however, is how the body's genome sustains such destructive glitches ...
Feb 02, 2011 |
5 / 5 (2) |
0
|
