University of Michigan researchers are celebrating their discovery of a new plant biochemistry and its unusual ability to form cyclic peptides—molecules that hold promise in pharmaceuticals as they can bind to challenging ...
Biochemistry
Feb 14, 2024
0
102
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require ...
Biochemistry
Dec 28, 2023
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203
There is a need for new drugs. For example, many of the antibiotics that we have been using for a long time are becoming less effective. Chemists and pharmaceutical scientists are frantically searching for new active substances, ...
Biochemistry
Apr 13, 2023
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38
CycPeptMPDB, a novel database created by Tokyo Tech researchers, focuses on the membrane permeability of cyclic peptides and could accelerate the development of drugs based on these promising compounds. This database was ...
Biochemistry
Apr 5, 2023
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36
Cyclic peptides often exhibit low membrane permeability that can be significantly improved via amide-to-ester substitutions, as demonstrated by researchers from Tokyo Institute of Technology (Tokyo Tech). The utilization ...
Biochemistry
Mar 17, 2023
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65
A new paper published in Nature Communications presents research on unique peptides with anti-cancer potential.
Biochemistry
Nov 14, 2022
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283
The Australian stinging tree (Dendrocnide moroides) is a plant that many people avoid at all costs. The tree, which is a member of the nettle family, is covered in thin silicon needles laced with one of nature's most excruciating ...
Biochemistry
Apr 21, 2022
0
106
Scientists at Tokyo Institute of Technology have developed a computational method based on large-scale molecular dynamics simulations to predict the cell-membrane permeability of cyclic peptides using a supercomputer. Their ...
Cell & Microbiology
Jul 13, 2021
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6
Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, ...
Biochemistry
Feb 22, 2021
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13
NUS researchers have identified post-translational modifying enzymes in bacteria that can create a new family of cyclic peptides for new therapeutics.
Biochemistry
Oct 15, 2020
0
40
