News tagged with clinical investigation
Glowing Cornell dots -- a potential cancer diagnostic tool set for human trials
The U.S. Food and Drug Administration (FDA) has approved the first clinical trial in humans of a new technology: Cornell Dots, brightly glowing nanoparticles that can light up cancer cells in PET-optical imaging.
Nanotechnology / Bio & Medicine
Jun 13, 2011 |
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Mouse cancer genome unveils genetic errors in human cancers
Scientists who pioneered sequencing the genomes of cancer patients to find novel genetic changes at the root of the disease now have turned their attention to a laboratory workhorse -- a mouse.
Mar 23, 2011 |
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Investigations show that telomerase inhibitor PinX1 is a key tumor suppressor
It's been nearly 10 years since Beth Israel Deaconess Medical Center (BIDMC) scientists Kun Ping Lu, MD, PhD and Xiao Zhen Zhou, MD, discovered PinX1, the first potent endogenous protein shown to inhibit telomerase in mammals.
Mar 23, 2011 |
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Trigger found for autoimmune heart attacks
People with type 1 diabetes, whose insulin-producing cells have been destroyed by the body's own immune system, are particularly vulnerable to a form of inflammatory heart disease (myocarditis) caused by a different autoimmune ...
Medicine & Health / Medical research
Mar 23, 2011 |
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Study puts notch on the jagged edge of lung cancer metastasis
Researchers discovered a new, key component in the spread of lung cancer as well as a likely way to block it with drugs now in clinical trial. The study was published today (Monday, March 14) in the Journal of Clinical In ...
Mar 14, 2011 |
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New method allows human embryonic stem cells to avoid immune system rejection
A short-term treatment with three immune-dampening drugs allowed human embryonic stem cells to survive and thrive in mice, according to researchers at the Stanford University School of Medicine. Without such treatment, the ...
Medicine & Health / Medical research
Mar 03, 2011 |
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Researchers uncover hormone pathway to fatty liver disease
Scientists at the UCSF Cardiovascular Research Institute have discovered how a change in growth hormone activity in mice leads to fatty liver disease, a condition whose human counterpart is of rising concern worldwide.
Medicine & Health / Medical research
Mar 01, 2011 |
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Cancer-related pathways reveal potential treatment target for congenital heart disease
(PhysOrg.com) -- Cross-disciplinary teams of scientists studying genetic pathways that are mutated in many forms of cancer, but which also cause certain forms of congenital heart disease, including hypertrophic cardiomyopathy ...
Feb 22, 2011 |
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Study shows rapamycin reverses myocardial defects in mouse model of LEOPARD syndrome
Congenital heart diseases affect approximately one in 100 patients, making them the most common type of birth defect and the number-one cause of pediatric deaths.
Feb 21, 2011 |
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An early step in Parkinson's disease: Problems with mitochondria
For the last several years, neurologists have been probing a connection between Parkinson's disease and problems with mitochondria, the miniature power plants of the cell.
Medicine & Health / Diseases, Conditions, Syndromes
Feb 14, 2011 |
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Gene protects lung from damage due to pneumonia, sepsis, trauma, transplants
Lung injury is a common cause of death among patients with pneumonia, sepsis or trauma and in those who have had lung transplants. The damage often occurs suddenly and can cause life-threatening breathing ...
Feb 08, 2011 |
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Unexpected new mechanism behind rheumatoid arthritis
A team of researchers at the University of Gothenburg, Sweden, has identified an enzyme that protects against inflammation and joint destruction. Made when the researchers blocked production of the enzyme GGTase-I in transgenic ...
Medicine & Health / Medical research
Feb 07, 2011 |
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Targeted particle fools brain's guardian to reach tumors
A targeted delivery combination selectively crosses the tight barrier that protects the brain from the bloodstream to home in on and bind to brain tumors, a research team led by scientists from The University of Texas MD ...
Feb 01, 2011 |
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Study raises safety concerns about experimental cancer approach
A study by researchers at Washington University School of Medicine in St. Louis has raised safety concerns about an investigational approach to treating cancer.
Jan 25, 2011 |
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Unfolding pathogenesis in Parkinson's
The study, published in the Journal of Clinical Investigation, reveals that damaged alpha-synuclein proteins (which are implicated in Parkinson's disease) can spread in a 'prion-like' manner, an infection model previously descri ...
Medicine & Health / Medical research
Jan 19, 2011 |
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