Linker histones tune the length and shape of chromosomes

Human life hinges on the ability of our cells to cram six feet of DNA into a 10-micron nucleus—equivalent to fitting a mile of string inside one green pea. But stuffing genes into cramped quarters is only half the battle. ...

When a chromosome is lost: How do human cells react to monosomy?

Human cells are usually diploid—they contain two sets of chromosome. Cells in which one chromosome is missing from the duplicated chromosome set are generally not viable. For a long time, the mechanisms responsible for ...

Highly dynamic sex chromosomes in cichlid fishes

The cichlids of Lake Tanganyika in Africa are highly diverse—including with regard to sex chromosomes. These have changed extremely frequently in the course of the evolution of these fish and, depending on the species, ...

Evolutionary 'arms race' may help keep cell division honest

Eggs and sperm are special cells for many reasons, but one of the characteristics that sets them apart is that unlike other human cells, which have two copies of 23 chromosomes, one from the mother and one from the father, ...

Protein complex SMC shown to ensures the dynamics of holocentromeres

Monocentromeres are typical for the chromosomes of most animals and plants. The centromere is necessary for the transport of the chromosomes and represents the connection point between the chromatids. This is how the classic ...

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