In higher organisms, detection of DNA in the cytoplasm triggers an immune reaction. The enzyme that senses "misplaced" DNA is also found in the nucleus, but nuclear DNA has no such effect. LMU researchers now report why that ...
Molecular & Computational biology
Sep 11, 2020
0
32
Our muscles start to shrink and weaken when we reach our 50s and 60s in a process called sarcopenia, but new research in mice from the University of Michigan offers new insights into why this loss may occur, and how we might ...
Cell & Microbiology
Aug 24, 2020
3
63
In eukaryotic cells, the genomic DNA is hierarchically packaged by histones into chromatin. Chromatin structure and its plasticity play an important role in the activation and silencing of gene transcription, and determine ...
Cell & Microbiology
Jul 29, 2020
0
18
Epigenetic regulation of gene expression is associated with switching between chromatin states characterized by distinct histone modifications.
Cell & Microbiology
Jun 30, 2020
0
120
RNA-mediated chromatin regulation is central to gene expression in many organisms but until now the mechanism of how RNA regulates chromatin packaging of DNA, and thereby switches genes on and off, has remained poorly understood.
Plants & Animals
Jun 19, 2020
0
383
In the cell, proteins often interact directly with DNA to regulate and influence the expression of genes. For this to happen, proteins need to travel into the cell's nucleus where the DNA is tightly twisted and packed as ...
Biotechnology
Jun 1, 2020
0
11
Researchers at Karolinska Institutet have developed a new sequencing method that makes it possible to map how DNA is spatially organized in the cell nucleus—revealing which genomic regions are at higher risk of mutation ...
Cell & Microbiology
May 26, 2020
0
24
The discovery of a huge number of long non-protein coding RNAs, aka lncRNAs, in the mammalian genome was a major surprise of the recent large-scale genomics projects. An international team including a bioinformatician from ...
Biotechnology
May 15, 2020
0
252
In a study published online in Nature Cell Biology on May 11, scientists from Guangzhou Institute of Biomedicine and Health (GIBH) of the Chinese Academy of Sciences established a novel and efficient system for non-integrated ...
Cell & Microbiology
May 14, 2020
0
41
The genetic information within cells makes individuals unique. The cell nucleus has a complex structure that harbors this genetic information. The main component of the nucleus is chromatin, an intercalated pool of genes ...
Biotechnology
May 12, 2020
0
6
