At the heart of brain diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease is protein misfolding, in which distorted proteins are unable to perform their normal functions. At ...
Cell & Microbiology
Jan 16, 2014
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(PhysOrg.com) -- Imagine two tango dancers sweeping across the dance floor and suddenly encountering a slick spot. To avoid a slip or even a nasty tumble, the pair must work together to support one another and glide safely ...
Cell & Microbiology
Mar 2, 2012
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All biological processes in our cells are constantly monitored to prevent the accumulation of defective proteins. In the worst case, such protein clumps can trigger diseases. The synthesis of new proteins is particularly ...
Cell & Microbiology
Jun 20, 2023
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248
(PhysOrg.com) -- The secret to fighting often lethal drug resistant fungal infections is to knock out the bug's molecular chaperone, according to U of T researchers.
Cell & Microbiology
Jul 31, 2009
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For proteins, this would be the equivalent of the red-carpet treatment: each protein belonging to the complex machinery of ribosomes—components of the cell that produce proteins—has its own chaperone to guide it to the ...
Cell & Microbiology
Feb 2, 2017
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171
(Phys.org)—A team of chemists and biologists led by Indiana University chemistry professor David Giedroc has described a previously unknown function of a protein they now know is responsible for protecting a major bacterial ...
Biochemistry
Jan 29, 2013
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Of the many marvels of the human immune system, the processing of antigens by the class I proteins of the major histocompatability complex (MHC-I) is among the most mind-boggling. Exactly how these proteins carry out their ...
Cell & Microbiology
Dec 3, 2019
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116
Studies at The University of Texas Health Science Center at San Antonio are providing basic new understanding about "heat shock proteins," also called "chaperone proteins." These proteins, first identified in cells subjected ...
Cell & Microbiology
Aug 5, 2016
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(PhysOrg.com) -- The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. ...
Analytical Chemistry
Nov 26, 2009
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(PhysOrg.com) -- The World Climate Conference recently took place. Reports about carbon dioxide levels, rising temperatures and melting glaciers appear daily. Scientists from the Max Planck Institute (MPI) of Biochemistry ...
Biochemistry
Jan 14, 2010
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